离子液体中铱催化苯甲酰胺与磺酰叠氮的 - 选择性碳 - 氢酰胺化反应
Iridium-catalyzed -selective carbon-hydrogen amidation of benzamides with sulfonyl azides in ionic liquid.
作者信息
Jiao Lin-Yu, Ning Zi-Hui, Hong Qian, Peng Xin-Hua, Yin Xiao-Mei, Liu Shanshan, Chen Huiyong, Li Zhuo, Sun Ming, Ma Xiao-Xun
机构信息
School of Chemical Engineering, Northwest University Xi'an Shaanxi 710069 P. R. China
International Scientific and Technological Cooperation Base for Clean Utilization of Hydrocarbon Resources, Chemical Engineering Research Center of the Ministry of Education for Advance Use Technology of Shanbei Energy, Shaanxi Research Center of Engineering Technology for Clean Coal Conversion, Collaborative Innovation Center for Development of Energy and Chemical Industry in Northern Shaanxi, Northwest University Xi'an Shaanxi 710069 P. R. China.
出版信息
RSC Adv. 2020 Aug 11;10(50):29712-29722. doi: 10.1039/d0ra05527a. eCollection 2020 Aug 10.
An efficient and convenient iridium(iii) catalyzed -C-H bond amidation of weakly coordinating benzamides treated with readily available sulfonyl azides as the amino source has been described. In this transformation, ionic liquids represents an ideal reaction medium, giving rise to a broad range of amidation products under mild conditions in the open air. This protocol offers moderate to excellent chemical yields, exclusive regioselectivities, and good functional group tolerance.
已经报道了一种高效便捷的铱（III）催化的弱配位苯甲酰胺的-C-H键酰胺化反应，该反应使用易于获得的磺酰叠氮化物作为氨基源。在这种转化中，离子液体是理想的反应介质，能在温和条件下于空气中产生多种酰胺化产物。该方法提供了中等至优异的化学产率、专一的区域选择性和良好的官能团耐受性。
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