Paediatric Neurology and Centro Clinico Nemo, Catholic University and Policlinico Gemelli, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy.
Departments of Rehabilitation and Regenerative Medicine, Columbia University Medical Center, New York, USA.
Muscle Nerve. 2019 Apr;59(4):426-430. doi: 10.1002/mus.26419. Epub 2019 Feb 7.
The aim of the study was to assess 12 month changes in upper limb function in patients affected by spinal muscular atrophy type 2 and 3.
Longitudinal 12 month data was collected in 114 patients, 60 type 2 and 54 type 3, using the Revised Upper Limb Module.
The 12 month changes ranged between -7 and 9 (mean: -0.41; SD: 2.93). The mean changes were not significantly different between the three spinal muscular atrophy groups (-0.45 in type 2, -0.23 in non-ambulant type 3 and -0.34 in ambulant type 3, p = 0.96) and the relationship between 12 month change and age classes was not significantly different among the three types of SMA patients.
Our results confirm that the Module explores a wide range of functional abilities and can be used in ambulant and non-ambulant patients of different ages in conjunction with other functional scales. Muscle Nerve 59:426-430, 2019.
本研究旨在评估脊髓性肌萎缩症 2 型和 3 型患者上肢功能在 12 个月内的变化。
114 例患者（60 例 2 型，54 例 3 型）接受了为期 12 个月的纵向数据收集，使用修订后的上肢模块进行评估。
12 个月的变化范围在-7 到 9 之间（平均值：-0.41；标准差：2.93）。三种脊髓性肌萎缩症组之间的平均变化无显著差异（2 型为-0.45，非运动型 3 型为-0.23，运动型 3 型为-0.34，p=0.96），而且三种类型的 SMA 患者之间 12 个月变化与年龄组的关系也无显著差异。
我们的结果证实，该模块可评估广泛的功能能力，并可与其他功能量表一起用于不同年龄的运动和非运动型患者。肌肉神经 59:426-430,2019。
