Department of Ophthalmology, Otto-von-Guericke University Magdeburg, Germany; Department of Ophthalmology, Martin-Luther University Halle, Germany.
Department of Ophthalmology, Otto-von-Guericke University Magdeburg, Germany; Beuth University of Applied Sciences, Berlin, Germany.
Clin Neurophysiol. 2019 Mar;130(3):379-387. doi: 10.1016/j.clinph.2018.11.030. Epub 2018 Dec 31.
To investigate the scope of scotopic multifocal visual evoked potentials (mfVEP) for the assessment of scotopic visual fields.
Pattern-reversal mfVEP for photopic (mfVEP) and scotopic conditions (mfVEP; 0.003 cd/m) were recorded from 36 visual field locations of a circular checkerboard pattern (25° radius) in 9 participants with normal vision. MfVEP were recorded with a conventional central fixation cross, mfVEP were recorded (i) with (mfVEP) and (ii) without (mfVEP) an additional fixation aid. Latency shifts were determined using cross-correlations, mfVEP magnitudes were analysed in an eccentricity dependent manner using signal-to-noise ratios (SNRs).
In comparison to mfVEP mfVEP and mfVEP were delayed by 101 ms and 97 ms, respectively, and had smaller signal-to-noise-ratios. Both mfVEP were reduced down to noise level in the center and also severely reduced for the most peripheral stimulus eccentricity used. The visual-field-coverage for the paracentral eccentricities of mfVEP and mfVEP was 76% and 65% [4°-9°], respectively, and 79% and 66% [9°-16°].
MfVEP were delayed compared to mfVEP and demonstrated the expected central response drop-out typical for scotopic vision.
MfVEP may hold promise of an objective, spatially resolved visual field test which motivates testing it in patients with diseases affecting scotopic vision.
研究暗视多焦视觉诱发电位（mfVEP）在暗视视野评估中的应用范围。
对 9 名正常视力者的 36 个圆形棋盘格图案（半径 25°）的视觉区域进行明视（mfVEP）和暗视（mfVEP；0.003cd/m）条件下的图形翻转 mfVEP 记录。mfVEP 采用传统的中央固定十字记录，mfVEP 记录时分别使用（mfVEP）和不使用（mfVEP）附加固定辅助工具。使用互相关确定潜伏期偏移，使用信噪比（SNR）分析 mfVEP 幅度的依赖于偏心度的方式。
与 mfVEP 相比，mfVEP 和 mfVEP 分别延迟了 101ms 和 97ms，并且 SNR 更小。mfVEP 和 mfVEP 的信号均在中心降至噪声水平，并且对于使用的最外围刺激偏心度也严重降低。mfVEP 和 mfVEP 的旁中心偏心度的视野覆盖率分别为 76%（4°-9°）和 65%，79%（9°-16°）和 66%。
与 mfVEP 相比，mfVEP 延迟，表现出暗视视觉典型的预期中心响应下降。
mfVEP 可能成为一种客观、空间分辨的视野测试方法，这促使我们在影响暗视视力的疾病患者中进行测试。
