Herbik A, Reupsch J, Thieme H, Hoffmann M B
Department of Ophthalmology, Otto-von-Guericke-University Magdeburg, Germany.
Department of Ophthalmology, Otto-von-Guericke-University Magdeburg, Germany.
Clin Neurophysiol. 2014 Dec;125(12):2418-26. doi: 10.1016/j.clinph.2014.03.017. Epub 2014 Mar 27.
To identify potential confounds in the comparison of simultaneously acquired multifocal electroretinograms (mfPERGs) and visual evoked potentials (mfVEPs) to pattern reversal stimulation.
With VERIS Science 5.1.10X monocular mfPERGs and mfVEPs were recorded simultaneously to optimised pattern-reversal stimulation for a reference condition and two filter conditions, i.e. blur and 8% luminance transmission, in two separate experiments in participants with normal vision. The impact of the filter conditions on mfPERG amplitude (P50 and N95 peaks), mfVEP-magnitude (root-mean-squares and signal-to-noise-ratios), and on the response timing was assessed.
Blur reduced mfPERG P50 and N95 amplitudes to 16%, 21%, and mfVEP magnitude to 82%. Decreasing stimulus luminance to 8% reduced only the mfPERG (P50 to 72% and N95 to 74%), but delayed both mfPERG and mfVEP responses by 5.3 and 4.6ms, respectively.
Comparatively minor stimulus manipulations, mimicking optic media opacities, had a differential effect on mfPERGs and mfVEPs magnitudes.
Simultaneous mfPERG/mfVEP recordings are a promising approach to compare retinal and cortical function, but caution must be exerted in the interpretation of response differences due to incongruent response characteristics.
确定在同时采集的多焦视网膜电图（mfPERG）和视觉诱发电位（mfVEP）与模式反转刺激比较中的潜在混杂因素。
在两项独立实验中，使用VERIS Science 5.1.10X对正常视力参与者同时记录单眼mfPERG和mfVEP，以优化模式反转刺激，设置一个参考条件和两个滤波条件，即模糊和8%亮度透射。评估滤波条件对mfPERG振幅（P50和N95峰）、mfVEP幅度（均方根和信噪比）以及反应时间的影响。
模糊使mfPERG的P50和N95振幅分别降至16%、21%，使mfVEP幅度降至82%。将刺激亮度降至8%仅使mfPERG降低（P50降至72%，N95降至74%），但分别使mfPERG和mfVEP反应延迟5.3毫秒和4.6毫秒。
模拟眼介质混浊的相对较小的刺激操作对mfPERG和mfVEP幅度有不同影响。
同时记录mfPERG/mfVEP是比较视网膜和皮质功能的一种有前景的方法，但由于反应特征不一致，在解释反应差异时必须谨慎。
