National Institute of Occupational Health, 0033 Oslo, Norway.
Department of Occupational and Environmental Medicine, University of Gothenburg, SE-405 30 Gothenburg, Sweden.
Int J Environ Res Public Health. 2019 Jan 23;16(3):300. doi: 10.3390/ijerph16030300.
The aim was to assess pneumoproteins and a certain biomarker of systemic inflammation in drill floor workers exposed to airborne contaminants generated during drilling offshore, taking into consideration serum biomarkers of smoking, such as nicotine (S-Nico) and cotinine. Blood samples of club cell protein 16 (CC-16), surfactant protein D (SP-D) and C-reactive protein (CRP) were collected before and after a 14-day work period from 65 drill floor workers and 65 referents. Air samples of oil mist, drilling mud components and elemental carbon were collected in person. The drill floor workers were exposed to a median air concentration of 0.18 mg/m³ of oil mist and 0.14 mg/m³ of airborne mud particles. There were no differences in the concentrations of CC-16 and SP-D across the 14-day work period and no difference between drill floor workers and referents at baseline after adjusting for differences in sampling time and smoking. CRP decreased across the work period. There was a strong association between the CC-16 concentrations and the time of sampling. Current smokers with S-Nico > detection limit (DL) had a statistically significantly lower CC-16 concentration, while smokers with S-Nico <DL had CC-16 concentrations similar to that of the non-smokers. Fourteen days of work offshore had no effect on serum pneumoprotein and CRP concentrations. However, the time of blood sampling was observed to have a strong effect on the measured concentrations of CC-16. The effect of current smoking on the CC-16 concentrations appears to be dependent on the S-Nico concentrations.
目的是评估在钻台工作的工人在暴露于海上钻探过程中产生的空气污染物时的肺保护蛋白和特定的全身炎症生物标志物，同时考虑到吸烟的血清生物标志物，如尼古丁（S-Nico）和可替宁。在 14 天的工作周期前后，从 65 名钻台工人和 65 名对照者中采集了 16 型细胞蛋白（CC-16）、表面活性剂蛋白 D（SP-D）和 C 反应蛋白（CRP）的血液样本。个人采集了油雾、钻井泥浆成分和元素碳的空气样本。钻台工人的空气暴露浓度中位数为 0.18 毫克/立方米油雾和 0.14 毫克/立方米的空气泥浆颗粒。在 14 天的工作周期内，CC-16 和 SP-D 的浓度没有差异，并且在调整采样时间和吸烟差异后，钻台工人和对照者在基线时也没有差异。CRP 在工作期间下降。CC-16 浓度与采样时间之间存在很强的相关性。S-Nico 超过检测限（DL）的当前吸烟者的 CC-16 浓度显著降低，而 S-Nico <DL 的吸烟者的 CC-16 浓度与非吸烟者相似。在海上工作 14 天对血清肺蛋白和 CRP 浓度没有影响。然而，血液采样时间对 CC-16 的测量浓度有很强的影响。当前吸烟对 CC-16 浓度的影响似乎取决于 S-Nico 浓度。
