Ellingsen Dag G, Ulvestad Bente, Bakke Berit, Seljeflot Ingebjørg, Barregard Lars, Thomassen Yngvar
National Institute of Occupational Health, P.O. Box 8149 Dep, 0033, Oslo, Norway.
Department of Occupational Medicine, Mesta AS, Moss, Norway.
Int Arch Occup Environ Health. 2015 Oct;88(7):943-51. doi: 10.1007/s00420-015-1023-4. Epub 2015 Jan 30.
The aim was to study inflammatory biomarkers in tunnel construction workers (TCW).
Surfactant protein D (SP-D), Clara cell protein 16 (CC-16) and C-reactive protein (CRP) were studied in serum of 90 TCW and 50 referents before and at the end of an 11-day work period. Personal air sampling was carried out on the two consecutive days before follow-up.
The TCW's geometric mean exposure to particulate matter and α-quartz were 604 and 74 µg/m(3), respectively. The arithmetic mean concentration of elemental carbon was 51 µg/m(3). The arithmetic mean concentration of SP-D was reduced by 7.6 µg/L in the TCWs and 0.6 µg/L in the referents (p = 0.04) at the end as compared to before the work period. Subjects who had ever been TCW had lower arithmetic mean CC-16 concentrations at baseline (5.4 µg/L) than subjects who had never worked as TCW (6.4 µg/L). Years worked as TCW was significantly associated with an annual mean decline of the CC-16 concentration of 0.04 µg/L. The concentrations of the biomarker of systemic inflammation, CRP, were not affected by exposure in the TCWs. Current smoking and body mass index have a large impact on the measured biomarker concentrations.
The results suggest that former and current TCWs have lower serum CC-16 concentrations than referents, while the concentrations of SP-D decreased during exposure. The serum biomarker of systemic inflammation, CRP, was not altered during exposure. Current smoking and BMI were related to the concentrations of all measured biomarkers.
研究隧道建设工人（TCW）体内的炎症生物标志物。
在90名隧道建设工人和50名对照人员工作11天前后，检测其血清中的表面活性蛋白D（SP-D）、克拉拉细胞蛋白16（CC-16）和C反应蛋白（CRP）。在随访前连续两天进行个人空气采样。
隧道建设工人对颗粒物和α-石英的几何平均暴露量分别为604和74μg/m³。元素碳的算术平均浓度为51μg/m³。与工作期开始前相比，工作期末隧道建设工人血清中SP-D的算术平均浓度降低了7.6μg/L，对照人员降低了0.6μg/L（p = 0.04）。曾经是隧道建设工人的受试者在基线时的CC-16算术平均浓度（5.4μg/L）低于从未从事过隧道建设工作的受试者（6.4μg/L）。作为隧道建设工人的工作年限与CC-16浓度每年平均下降0.04μg/L显著相关。全身炎症生物标志物CRP的浓度在隧道建设工人中不受暴露影响。当前吸烟和体重指数对所测生物标志物浓度有很大影响。
结果表明，曾经和现在的隧道建设工人血清CC-16浓度低于对照人员，而暴露期间SP-D浓度下降。全身炎症血清生物标志物CRP在暴露期间未改变。当前吸烟和体重指数与所有所测生物标志物的浓度有关。
