School of Materials Science and Engineering, Beihang University, Beijing 100191, China; Key Laboratory of Aerospace Advanced Materials and Performance (Beihang University), Ministry of Education, Beijing 100191, China; Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University, Beijing 100191, China.
College of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China.
Mater Sci Eng C Mater Biol Appl. 2019 Apr;97:254-263. doi: 10.1016/j.msec.2018.12.031. Epub 2018 Dec 12.
Magnesium has a very promising adhibition in biomedical field for its excellent mechanical and biodegradable properties, however, the intelligent applications of biomedical magnesium developed difficultly due to its characteristic degradation. A intelligent biomedical magnesium was constructed on magnesium (Mg) surface by incorporating polydopamine (PD) and mechanized hollow mesoporous silica nanoparticles (HMSs) as smart delivery platform nanocontainers. The supramolecular nanovalves of mechanized HMSs consisted of alginate/chitosan multilayers by self-assembly, which are capable of entrapping rhodamine 6G in the mesopores and can release the cargo under the chemical environment of alkali or Mg iron stimuli that correspond to the degradation of biomedical Mg. The alkali/Mg dual stimuli-responsive release property of the HMSs endows the biodegradable Mg with controlled release potential. The well-designed smart delivery nanocontainers were combined with polydopamine deposited on Mg for excellent adhesion properties and positively charged amino group of PD. Furthermore, when the biomedical Mg with these mechanized HMSs was degraded in the simulated body environment, the alkali/Mg-triggered release of cargos from this smart delivery platform could bring a more functional application.
镁因其出色的机械和可生物降解性能，在生物医学领域具有广阔的应用前景，然而，由于其自身的降解特性，生物医学镁的智能应用发展较为困难。本研究通过在镁（Mg）表面结合聚多巴胺（PD）和机械中空介孔硅纳米颗粒（HMSs），构建了一种智能生物医学镁。作为智能药物输送平台纳米容器，机械 HMSs 的超分子纳米阀由海藻酸钠/壳聚糖多层自组装而成，能够将罗丹明 6G 包埋在介孔中，并在碱或 Mg-Fe 刺激的化学环境下释放货物，这与生物医学镁的降解相对应。HMSs 的碱/Mg 双重刺激响应释放特性赋予了可生物降解的镁控释潜力。精心设计的智能输送纳米容器与沉积在镁上的聚多巴胺结合，具有优异的附着力和 PD 的正电荷氨基。此外，当具有这些机械 HMSs 的生物医学镁在模拟体液环境中降解时，该智能输送平台中货物的碱/Mg 触发释放可以带来更具功能性的应用。
