Department of Chemical, Polymer & Composite Materials Engineering, University of Engineering & Technology, KSK Campus, Lahore 54890, Pakistan; Faculty of Civil Engineering and Geosciences, Department of Hydraulic Engineering, Rivers, Ports, Waterways and Dredging Engineering, Delft University of Technology, Stevinweg 1, 2628 CN Delft, the Netherlands.
Department of Chemical, Polymer & Composite Materials Engineering, University of Engineering & Technology, KSK Campus, Lahore 54890, Pakistan.
Mater Sci Eng C Mater Biol Appl. 2019 Apr;97:932-953. doi: 10.1016/j.msec.2018.12.075. Epub 2018 Dec 26.
Bigels are interesting semisolid formulations with better properties for different applications such as cosmetics and pharmaceutical systems. Due to the mixing of two phases of different nature (polar and apolar), bigels possess some interesting features like ability to deliver hydrophilic and hydrophobic drugs, better spreadability and water washability, improved permeability of drugs, enhanced hydration of stratum corneum and ability to manipulate the drug release rate. The main objective of this review article is to provide a thorough insight into the important characteristics of bigels together with the discussion on modelling of bigel systems to relate their properties with individual constituents and different parameters. Moreover, some important applications of bigels are also discussed by considering some examples from the literature.
双凝胶是一种有趣的半固态制剂，具有更好的性能，适用于化妆品和药物等不同领域。由于两种不同性质（极性和非极性）相的混合，双凝胶具有一些有趣的特点，如能够传递亲水和疏水药物、更好的铺展性和水洗性、改善药物渗透性、增强角质层的水合作用以及控制药物释放速度的能力。本文综述的主要目的是深入了解双凝胶的重要特性，并讨论双凝胶系统的建模，以将其性质与各组分和不同参数联系起来。此外，还通过考虑文献中的一些实例，讨论了双凝胶的一些重要应用。
