State Key Laboratory of Biotherapy and Cancer Center, West China Hospital and West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, P.R. China; These authors contributed equally to this work.
Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, P.R. China.
Trends Biochem Sci. 2019 May;44(5):401-414. doi: 10.1016/j.tibs.2019.01.001. Epub 2019 Jan 21.
Metabolic alterations and elevated levels of reactive oxygen species (ROS) are two characteristics of cancer. The metabolic patterns of cancer cells are elaborately reprogrammed to fulfill the high biomass demands of rapid propagation. ROS, the byproducts of metabolic processes, are accumulated in cancer cells partially due to metabolic abnormalities or oncogenic mutations. To prevent oxidative damage, cancer cells can orchestrate metabolic adaptation to maintain reduction-oxidation (redox) balance by producing reducing equivalents. ROS, acting as second messengers, can in turn manipulate metabolic pathways by directly or indirectly affecting the function of metabolic enzymes. In this review we discuss how cancer cell metabolism and redox signaling are intertwined, with an emphasis on the perspective of targeting metabolic-redox circuits for cancer therapy.
代谢改变和活性氧（ROS）水平升高是癌症的两个特征。癌细胞的代谢模式被精心重编程以满足快速增殖的高生物质需求。ROS 是代谢过程的副产物，部分由于代谢异常或致癌突变而在癌细胞中积累。为了防止氧化损伤，癌细胞可以通过产生还原当量来协调代谢适应，以维持氧化还原（redox）平衡。ROS 作为第二信使，可以通过直接或间接影响代谢酶的功能来反过来操纵代谢途径。在这篇综述中，我们讨论了癌细胞代谢和氧化还原信号之间的相互交织，并强调了针对代谢-氧化还原电路进行癌症治疗的观点。
