Department of Ophthalmology, College of Medicine, University of Ulsan, Gangneung Asan Hospital, Gangneung, Korea.
Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea.
Br J Ophthalmol. 2019 Dec;103(12):1827-1833. doi: 10.1136/bjophthalmol-2018-313019. Epub 2019 Jan 24.
To evaluate the relationship between macular vessel density (mVD) and central visual field sensitivity (cVFS) at different stages of glaucoma and to compare this relationship with that between the thickness of the macular ganglion cell-inner plexiform layer (mGCIPLT) and cVFS.
The mVD and mGCIPLT were measured by optical coherence tomography angiography in 139 patients with glaucoma. The cVFS was defined as the average of 12 central points on 24-2 visual field (VF) testing. Vasculature-function and structure-function relationships were analysed by comparing mVD and mGCIPLT with cVFS in eyes with early and moderate-to-advanced glaucoma.
Global and regional mVD-cVFS associations were statistically significant in eyes with moderate-to-advanced (all p<0.05), but not early stage (all p>0.05) glaucoma. The global association between average mVD and cVFS was significantly stronger than that between average mGCIPLT and cVFS in eyes with moderate-to-advanced glaucoma (p=0.049). Reduced mVD was independently associated with cVFS loss after adjusting for age and mGCIPLT in eyes with moderate-to-advanced glaucoma.
The macular vasculature-function relationship using mVD was stronger than the structure-function relationship using mGCIPLT in eyes with moderate-to-advanced glaucoma. The mVD may be useful in monitoring cVFS in advanced glaucoma.
评估青光眼不同阶段黄斑血管密度（mVD）与中心视野敏感度（cVFS）之间的关系，并将其与黄斑神经节细胞-内丛状层（mGCIPLT）厚度与 cVFS 之间的关系进行比较。
通过光学相干断层扫描血管造影术测量 139 例青光眼患者的 mVD 和 mGCIPLT。cVFS 定义为 24-2 视野（VF）测试的 12 个中央点的平均值。通过比较早期和中晚期青光眼眼中的 mVD 和 mGCIPLT 与 cVFS，分析血管功能-结构功能关系。
中晚期（均 p<0.05）而非早期（均 p>0.05）青光眼眼中，全局和局部 mVD-cVFS 相关性具有统计学意义。中晚期青光眼眼中，平均 mVD 与 cVFS 的总体相关性明显强于平均 mGCIPLT 与 cVFS 的相关性（p=0.049）。调整年龄和 mGCIPLT 后，中晚期青光眼眼中，mVD 降低与 cVFS 损失独立相关。
在中晚期青光眼眼中，使用 mVD 的黄斑血管功能关系强于使用 mGCIPLT 的结构-功能关系。mVD 可能有助于监测晚期青光眼的 cVFS。
