Department of Ophthalmology, Asan Medical Center, College of Medicine University of Ulsan, Seoul, Korea.
J Glaucoma. 2020 May;29(5):381-385. doi: 10.1097/IJG.0000000000001464.
Pseudoexfoliation glaucoma eyes had a similar level of peripapillary and superficial macular vessel densities compared with primary open-angle glaucoma eyes matched for age and glaucoma severity when assessed by optical coherence tomography angiography (OCT-A).
To compare vessel density (VD) measured by OCT-A between primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXG) in the peripapillary and macular areas.
The circumpapillary (cpVD), parafoveal (pfVD), and perifoveal vessel densities (perifVD) were obtained using OCT-A (AngioVue/RTVue-XR) in 98 eyes from 98 subjects [age, visual acuity, visual field (VF) mean deviation (MD) matched 49 POAG and 49 PXG eyes]. Global and 8 sectoral VDs in the peripapillary capillary layer were compared. In the macula, the superficial and deep layers of the pfVD and perifVD were analyzed globally and in 4 quadrants. Univariate and multivariate linear regression models were built using cpVD, pfVD, and perifVD as dependent variables and covariates [age, intraocular pressure (IOP), axial length, signal strength index (SSI), and retinal nerve fiber layer (RNFL) thickness] were considered independent variables.
In the peripapillary region, none of the VDs differed between groups both before and after adjustment. When we adjusted superficial and deep layer macular VDs for age, IOP, SSI, axial length, and RNFL thickness, all of which could affect measurements, the 2 groups did not differ in any sector. The cpVD in POAG eyes significantly correlated with VF MD and RNFL thickness, whereas IOP, VF MD, and RNFL thickness affected cpVD in PXG. The macular VD in the deep layer was associated with only SSI in both groups.
Age-matched and glaucoma severity-matched PXG and POAG did not significantly differ in cpVD or in most of the superficial macular VD parameters.
与原发性开角型青光眼（POAG）相比，经光学相干断层扫描血管造影（OCT-A）评估年龄和青光眼严重程度匹配的假性剥脱性青光眼（PXG）眼的周边和浅层黄斑血管密度相似。
比较原发性开角型青光眼（POAG）和假性剥脱性青光眼（PXG）在周边和黄斑区域的 OCT-A 测量的血管密度（VD）。
使用 OCT-A（AngioVue/RTVue-XR）在 98 名患者的 98 只眼中获得了 98 只眼的周边（cpVD）、旁中心凹（pfVD）和周边黄斑血管密度（perifVD）。比较了周边毛细血管层的全局和 8 个扇形血管密度。在黄斑区，分析了 pfVD 和 perifVD 的浅层和深层全局以及 4 个象限。使用 cpVD、pfVD 和 perifVD 作为因变量，年龄、眼内压（IOP）、眼轴长度、信号强度指数（SSI）和视网膜神经纤维层（RNFL）厚度作为协变量建立单变量和多变量线性回归模型。
在周边区域，在调整前后，两组之间的任何血管密度均无差异。当我们根据年龄、IOP、SSI、眼轴长度和 RNFL 厚度调整浅层和深层黄斑 VD 时，所有这些因素都可能影响测量结果，两组在任何一个区域都没有差异。POAG 眼的 cpVD 与视野 MD 和 RNFL 厚度显著相关，而 IOP、VF MD 和 RNFL 厚度影响 PXG 的 cpVD。两组的深层黄斑 VD 仅与 SSI 相关。
年龄匹配和青光眼严重程度匹配的 PXG 和 POAG 在 cpVD 或大多数浅层黄斑 VD 参数方面没有显著差异。
