使用定量对比增强 MRI 测量人脑的神经胶质淋巴液流动。
Measuring Glymphatic Flow in Man Using Quantitative Contrast-Enhanced MRI.
机构信息
From the Department of Radiology (R.W.), University of Vermont, Burlington, Vermont.
Department of Radiology (J.M.S., L.W., X.Z., C.G.F.), Lenox Hill Hospital and Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, East Garden City, New York.
出版信息
AJNR Am J Neuroradiol. 2019 Apr;40(4):648-651. doi: 10.3174/ajnr.A5931. Epub 2019 Jan 24.
Abstract
On the basis of animal models, glymphatic flow disruption is hypothesized to be a factor in the development of Alzheimer's disease. We report the first quantitative study of glymphatic flow in man, combining intrathecal administration of gadobutrol with serial T1 mapping to produce contrast concentration maps up to 3 days postinjection, demonstrating performing a quantitative study using the techniques described feasibility and providing data on pharmacokinetics.
摘要
基于动物模型，人们假设糖质淋流破坏是阿尔茨海默病发展的一个因素。我们报告了首例对人类糖质淋流的定量研究，该研究将加碘布醇鞘内给药与连续 T1 映射相结合，在注射后 3 天内产生对比浓度图，证明了使用所述技术进行定量研究的可行性，并提供了关于药代动力学的相关数据。
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