基于人群的糖尿病黄斑水肿研究概况：利物浦眼与糖尿病研究（悉尼）。

Profile of a population-based diabetic macular oedema study: the Liverpool Eye and Diabetes Study (Sydney).

机构信息

South West Retina, Retina Associates, Liverpool, New South Wales, Australia.

Centre for Vision Research, Westmead Millennium Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia.

出版信息

BMJ Open. 2019 Jan 24;9(1):e021884. doi: 10.1136/bmjopen-2018-021884.

DOI:10.1136/bmjopen-2018-021884

PMID:30679285

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6347905/

Abstract

PURPOSE

The population prevalence of diabetic macular oedema (DME) is unclear. Previous estimates have depended on photographic grading of clinically significant macular oedema, which is subjective and has resulted in widely varying estimates. With the advent of optical coherence tomography (OCT), the presence and severity of DME can now be assessed objectively and accurately.

METHODS

The Liverpool Eye and Diabetes Study (LEADS) is a cross-sectional population-based study of patients with type 1 and type 2 diabetes in a multi-ethnic region of Sydney, Australia, to determine the population prevalence of OCT-defined DME, how this varies by ethnicity and association with systemic factors. This report describes the rationale, methodology and study aims.

RESULTS

To date 646 patients out of an expected sample size of 2000 have been recruited. Baseline data are presented for patients with type 1 (n=75, 11.8%) and type 2 (n=562, 88.2%) diabetes recruited to date. Patients with type 1 diabetes were younger (39.5vs60.7 years), with longer duration of diabetes (18.1vs11.7 years), slightly worse glycaemic control (HbA1c 9.0vs8.3), and less likely to have hypertension (30.7vs71.4%), hypercholesterolaemia (33.3vs74.6%) and obesity (31.1vs51.5%, respectively, all p<0.05).

CONCLUSIONS

The LEADS will provide objective estimates of the population prevalence of DME, how this varies with ethnicity and associations with systemic disease.

摘要

目的

糖尿病性黄斑水肿（DME）的人群患病率尚不清楚。以前的估计取决于对有临床意义的黄斑水肿进行照相分级，这种方法是主观的，导致估计结果差异很大。随着光学相干断层扫描（OCT）的出现，现在可以客观和准确地评估 DME 的存在和严重程度。

方法

利物浦眼与糖尿病研究（LEADS）是一项在澳大利亚悉尼一个多民族地区进行的 1 型和 2 型糖尿病患者的横断面人群研究，旨在确定 OCT 定义的 DME 的人群患病率，其在不同种族中的差异以及与全身因素的关系。本报告描述了研究的原理、方法和目的。

结果

迄今为止，已招募了预计 2000 名患者中的 646 名。目前报告了已招募的 1 型（n=75，11.8%）和 2 型（n=562，88.2%）糖尿病患者的基线数据。1 型糖尿病患者更年轻（39.5 岁比 60.7 岁），糖尿病病程更长（18.1 年比 11.7 年），血糖控制略差（HbA1c 9.0 比 8.3），高血压（30.7%比 71.4%）、高胆固醇血症（33.3%比 74.6%）和肥胖症（31.1%比 51.5%）的可能性也较低（所有 p<0.05）。