Miyake Sanae, Shindo Ryodai, Nakano Hiroyasu
Department of Biochemistry, Toho University School of Medicine, Tokyo, Japan.
Clin Calcium. 2019;29(2):248-253. doi: 10.20837/4201902248.
Apoptosis is a prototype of regulated cell death and plays a crucial role in the development of various organs and maintaining tissue homeostasis. Recent studies have revealed that new types of regulated cell death, including necroptosis, ferroptosis, and pyroptosis are molecularly identified. In this review, we discuss the molecular mechanisms and the functions of new types of regulated cell death.
细胞凋亡是程序性细胞死亡的典型形式,在各种器官的发育和维持组织稳态中发挥着关键作用。最近的研究表明,包括坏死性凋亡、铁死亡和焦亡在内的新型程序性细胞死亡已在分子层面得到确认。在本综述中,我们将讨论新型程序性细胞死亡的分子机制及其功能。