环孢素A和胰岛素对BB/W大鼠外周淋巴细胞的影响。

Effects of cyclosporin A and insulin on peripheral lymphocytes in BB/W rats.

作者信息

Suzuki M, Kawazu S, Negishi K, Shunto S, Takahashi M, Watanabe T, Katayama S, Ushi J, Komeda K

机构信息

Fourth Department of Internal Medicine, Saitama Medical School, Japan.

出版信息

Diabetes Res. 1988 Jul;8(3):123-8.

PMID:3067953

Abstract

The effects of cyclosporin A (Cs-A) and insulin on peripheral lymphocytes in BB/W rats were studied. The cumulative incidence of overt diabetes in untreated BB/W rats was 72% up to 120 days of observation, whereas the incidence was 13% in Cs-A-treated rats. Lymphocytopenia, consisting of decreased OX19+ (pan T), W3/25+ (helper/inducer T) and OX8+ (cytotoxic/suppressor T) cells, was present in BB/W rats. Cs-A significantly decreased both the percentage and the absolute number of OX8+, OX6+ (Ia-positive) and OX12+ (B) cells, and augmented the ratio of W3/25+ to OX8+ cells in BB/W rats. On the other hand, insulin injection significantly decreased the percentage of OX6+ cells and the ratio of W3/25+ to OX8+ cells in BB/W rats. Thus, rearrangement of the ratio of helper/inducer T to cytotoxic/suppressor T cells and reduction in the number of Ia antigen-bearing cells could be important for the inhibitory effects of diabetes in BB/W rats upon treatment with Cs-A or insulin.

摘要

研究了环孢素A（Cs - A）和胰岛素对BB/W大鼠外周淋巴细胞的影响。在长达120天的观察期内，未治疗的BB/W大鼠显性糖尿病的累积发病率为72%，而Cs - A治疗组大鼠的发病率为13%。BB/W大鼠存在淋巴细胞减少，表现为OX19 +（全T细胞）、W3/25 +（辅助/诱导性T细胞）和OX8 +（细胞毒性/抑制性T细胞）细胞数量减少。Cs - A显著降低了BB/W大鼠中OX8 +、OX6 +（Ia阳性）和OX12 +（B细胞）细胞的百分比和绝对数量，并增加了W3/25 +与OX8 +细胞的比例。另一方面，胰岛素注射显著降低了BB/W大鼠中OX6 +细胞的百分比以及W3/25 +与OX8 +细胞的比例。因此，辅助/诱导性T细胞与细胞毒性/抑制性T细胞比例的重新调整以及Ia抗原阳性细胞数量的减少，可能对Cs - A或胰岛素治疗BB/W大鼠糖尿病的抑制作用具有重要意义。