BB/W大鼠巨噬细胞上的主要组织相容性复合体II类分子（Ia抗原）
MHC class II molecules (Ia-antigens) on macrophages in BB/W rats.
作者信息
Suzuki M, Kawazu S, Negishi K, Shunto S, Moritani S, Inoue I, Takei S, Ishii J, Komeda K
机构信息
Fourth Department of Internal Medicine, Saitama Medical School, Japan.
出版信息
Diabetes Res. 1990 May;14(1):5-7.
The percentage, absolute number and expression of Ia-antigen of macrophages (Mø) in peripheral blood cells (PBC) and splenocytes from Bio-Breeding/Worcester (BB/W) rats were evaluated. The percentage of Mø in PBC and splenocytes from BB/W rats was significantly higher than those in normal Wistar rats from Clea Japan Inc. (NW/C) and Charles River Japan Inc. (NW/CR). The percentage of Ia-positive Mø in PBC and splenocytes from BB/W rats was significantly increased compared with that in NW/C rats. On the other hand, there was no significant difference in the percentage of Ia-positive Mø of PBC between BB/W and NW/CR rats, and the percentage of Ia-positive Mø in the spleen from BB/W rats was significantly lower than those in NW/CR rats. Thus, the quantity of MHC class II molecules on circulating Mø is not related to the pathogenesis of diabetes mellitus in BB/W rats.
对Bio-Breeding/Worcester（BB/W）大鼠外周血细胞（PBC）和脾细胞中巨噬细胞（Mø）的Ia抗原百分比、绝对数量和表达进行了评估。BB/W大鼠PBC和脾细胞中Mø的百分比显著高于日本Clea公司（NW/C）和日本Charles River公司（NW/CR）的正常Wistar大鼠。与NW/C大鼠相比，BB/W大鼠PBC和脾细胞中Ia阳性Mø的百分比显著增加。另一方面，BB/W大鼠和NW/CR大鼠PBC中Ia阳性Mø的百分比无显著差异，且BB/W大鼠脾脏中Ia阳性Mø的百分比显著低于NW/CR大鼠。因此，循环中Mø上MHC II类分子的数量与BB/W大鼠糖尿病的发病机制无关。
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