Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Sci Rep. 2019 Jan 24;9(1):575. doi: 10.1038/s41598-018-38160-8.
To compare the surgical outcomes of adult intermittent exotropia (X(T)) patients and matched control children X(T) patients including survival analysis. Fifty-two adult X(T) patients and 129 matched control children X(T) patients were included. Clinical characteristics, survival analysis, and surgical dose-response curves were evaluated and compared between the two groups. The weighted Cox proportional hazards regression analysis was used in order to find risk factors for the recurrence. Using Kaplan-Meier survival analysis, the cumulative probability of survival rate considering recurrence as event of Adult group were 93.97% for one year, and maintained at 88.44% for two, three. four, and five years after surgery. In contrast, those of the Child group were 83.6%, 76.5%, 65.6%, 56.23%, and 40.16% for one, two, three, four, and five years after surgery, respectively. The Adult group had a better event-free survival curve than the Child group as analyzed by a Log-rank test (p = 0.020). According to multivariate weighted Cox regression analysis, the younger age at operation and the larger preoperative angle were significant risk factors for recurrence.
比较成人间歇性外斜视（X(T)）患者和匹配的儿童 X(T)患者的手术结果，包括生存分析。
纳入 52 例成人 X(T)患者和 129 例匹配的儿童 X(T)患者。评估并比较两组患者的临床特征、生存分析和手术剂量反应曲线。使用加权 Cox 比例风险回归分析寻找复发的危险因素。采用 Kaplan-Meier 生存分析，以复发为事件，考虑成人组一年的累积生存率为 93.97%，两年、三年、四年和五年后分别维持在 88.44%、76.5%、65.6%、56.23%和 40.16%。相比之下，儿童组术后一年、两年、三年、四年和五年的累积生存率分别为 83.6%、76.5%、65.6%、56.23%和 40.16%。Log-rank 检验分析表明，成人组的无事件生存曲线优于儿童组（p=0.020）。多变量加权 Cox 回归分析显示，手术时年龄较小和术前角度较大是复发的显著危险因素。
