谷胱甘肽过氧化物酶在眼组织中的免疫组织化学定位
Immunohistochemical localization of glutathione peroxidase in ocular tissue.
作者信息
Atalla L R, Sevanian A, Rao N A
机构信息
Estelle Doheny Eye Institute, Department of Ophthalmology, University of Southern California, Los Angeles.
出版信息
Curr Eye Res. 1988 Oct;7(10):1023-7. doi: 10.3109/02713688809015149.
In this study enzyme glutathione peroxidase was localized in ocular tissue of Lewis rats using the peroxidase antiperoxidase immunohistochemical technique. Antisera to glutathione peroxidase was raised in a rabbit. Immunoreactive glutathione peroxidase was found to be distributed predominantly in the corneal epithelium and endothelium, choroid, inner segment of photoreceptors and retinal pigmented epithelium. Its presence in these sites suggests an adaptation to oxidative stress where this antioxidant enzyme along with other antioxidant systems serves to prevent damage.
在本研究中，使用过氧化物酶抗过氧化物酶免疫组织化学技术，将谷胱甘肽过氧化物酶定位在Lewis大鼠的眼组织中。用兔制备了抗谷胱甘肽过氧化物酶抗血清。发现免疫反应性谷胱甘肽过氧化物酶主要分布在角膜上皮和内皮、脉络膜、光感受器内段和视网膜色素上皮。它在这些部位的存在表明对氧化应激的一种适应，在这种情况下，这种抗氧化酶与其他抗氧化系统一起起到防止损伤的作用。
Zotero 插件