Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA.
Ocul Surf. 2009 Oct;7(4):176-85. doi: 10.1016/s1542-0124(12)70185-4.
The human eye is subjected constantly to oxidative stress due to daily exposure to sunlight, high metabolic activities, and oxygen tension. Reactive oxygen species generated from environmental insults and pathological conditions render the human eye particularly vulnerable to oxidative damage. The ocular surface composed of the tear film, the cornea, and the aqueous humor forms the first physical and biochemical barrier of the eye and plays a pivotal role in combating free radicals. These ocular compartments are enriched in certain antioxidants in the form of metabolic enzymes or small molecules. Such an antioxidant defense system in the ocular surface is essential for the maintenance of redox homeostasis in the eye and protection against oxidative damage. Herein, we review the properties and functions of key constituent antioxidants of the ocular surface.
由于每天暴露在阳光下、新陈代谢活动旺盛和氧气张力，人眼会不断受到氧化应激的影响。来自环境刺激和病理条件的活性氧物种使人类眼睛特别容易受到氧化损伤。由泪膜、角膜和房水组成的眼表面形成了眼睛的第一道物理和生化屏障，并在对抗自由基方面发挥着关键作用。这些眼部分富含某些抗氧化剂，形式为代谢酶或小分子。眼表面的这种抗氧化防御系统对于维持眼睛的氧化还原平衡和防止氧化损伤至关重要。在此，我们综述了眼表面关键组成抗氧化剂的特性和功能。
