Cook J D, Trotter J L, Engel W K, Sciabbarrasi J S
Ann Neurol. 1978 Feb;3(2):166-76. doi: 10.1002/ana.410030213.
Several immunological variables were examined in patients receiving high-single-dose, alternate-day prednisone therapy for neuromuscular diseases. Dose-dependent leukocytosis, lymphopenia, and monocytopenia occurred which were maximal 6 hours after prednisone administration but returned to control levels by the 24-hour point. The lymphopenia involved T-cells, B-cells, and null cells, with the T-cells most affected. Plasma cortisol levels and lymphocyte transformation in response to mitogens were also transiently and reversibly suppressed. There was a persistent decrease in serum IgG. Lymphocyte transformation was also suppressed when normal lymphocytes were incubated with treated patient sera or when treated patient lymphocytes were incubated in autologous pretreatment sera. The suppression factor was not removed from the lymphocytes by extensive washing. Patients whose disease responded to the high-single-dose, alternate-day prednisone regiment were indistinguishable from nonresponders by the immunological responses measured.
对接受高单次剂量隔日泼尼松治疗神经肌肉疾病的患者进行了多项免疫学变量检查。出现了剂量依赖性白细胞增多、淋巴细胞减少和单核细胞减少，在给予泼尼松后6小时达到最大值，但在24小时时恢复到对照水平。淋巴细胞减少涉及T细胞、B细胞和裸细胞，其中T细胞受影响最大。血浆皮质醇水平和对有丝分裂原的淋巴细胞转化也被短暂且可逆地抑制。血清IgG持续下降。当正常淋巴细胞与经治疗患者的血清一起孵育，或当经治疗患者的淋巴细胞在自体预处理血清中孵育时，淋巴细胞转化也受到抑制。通过广泛洗涤，抑制因子并未从淋巴细胞中去除。根据所测量的免疫反应，疾病对高单次剂量隔日泼尼松治疗方案有反应的患者与无反应者并无差异。
