Uchino M, Araki S, Yoshida O, Uekawa K, Nagata J
J Neurol. 1985;232(3):175-8. doi: 10.1007/BF00313897.
High single-dose alternate-day prednisolone therapy (ADT) was compared with daily-dose prednisolone therapy (DDT) for treatment of polymyositis. Thirty patients with polymyositis were treated with ADT for an average of 33.9 months. The combined number of improvements was 21 out of 30, a response rate of 70%. Side-effects were very rare and mild. On the other hand, 9 of 17 patients treated with DDT for an average 18.5 months improved, a response rate of 53%. The incidence of side-effects was strikingly higher than with ADT. ADT is therefore strongly advocated for treatment of polymyositis to avoid infectious complications and lessen cushingoid side-effects.
将高剂量隔日泼尼松疗法（ADT）与每日剂量泼尼松疗法（DDT）用于治疗多发性肌炎进行了比较。30例多发性肌炎患者接受了ADT治疗，平均治疗33.9个月。30例中有21例病情得到改善，有效率为70%。副作用非常罕见且轻微。另一方面，17例接受DDT治疗的患者中有9例病情改善，平均治疗18.5个月，有效率为53%。副作用的发生率明显高于ADT。因此，强烈主张采用ADT治疗多发性肌炎，以避免感染并发症并减轻库欣样副作用。
