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比较白内障手术中各种单片丙烯酸单焦点人工晶状体植入对医疗资源利用和成本的长期影响:英国、意大利和丹麦的成本效益分析。

Comparing the long-term impact on health care resources utilization and costs due to various single-piece acrylic monofocal intraocular lens implantation during cataract surgery: a cost-consequence analysis for the United Kingdom, Italy, and Denmark.

作者信息

Dhariwal Mukesh, Bouchet Christine, Jawla Shantanu

机构信息

Global Health Economics & Outcomes Research, Alcon Laboratories, Inc., Fort Worth, TX, USA,

Global Patient Access, Novartis Pharma AG, Basel, Switzerland.

出版信息

Clin Ophthalmol. 2019 Jan 14;13:169-176. doi: 10.2147/OPTH.S190754. eCollection 2019.

Abstract

PURPOSE

The objective of this study was to estimate the cost impact of neodymium-doped yttrium aluminum garnet (Nd:YAG) laser capsulotomy and its complications due to single-piece acrylic monofocal intraocular lenses (IOLs) in the healthcare setting of United Kingdom, Italy, and Denmark.

MATERIALS AND METHODS

A hypothetical cost-consequence model was developed to estimate economic burden of Nd:YAG laser capsulotomy due to different single-piece acrylic monofocal IOLs. Cumulative incidence of Nd:YAG laser capsulotomy at 3 years after cataract surgery with five single-piece monofocal acrylic IOLs was sourced from retrospective data analysis of electronic medical records of cataract patients in the United Kingdom. Risk probability of post-Nd:YAG laser complications, ie, retinal detachment, glaucoma, and cystoid macular edema at 3 years was derived using published literature. Unit costs were taken from publicly available sources with all costs converted to euro (€). Number of cataract procedures per year for each country was sourced from Eurostat statistics.

RESULTS

For the estimated cataract procedures carried out nationally every year, single-piece monofocal hydrophobic AcrySof IOL was associated with substantially lower cases of Nd:YAG laser capsulotomy procedures and subsequent complications in 3 years after cataract surgery when compared to other single-piece monofocal acrylic IOLs. The total cost savings with the use of AcrySof over other IOLs in countries assessed ranged from €0.5 to €4.7 million (vs AMO Tecnis) and €2.1 to €17.9 million (vs Rayner C-/Super-flex).

CONCLUSION

Incidence of Nd:YAG capsulotomy due to the choice of IOL could significantly affect healthcare budgets in the post-cataract surgery period. Our analysis indicates that single-piece monofocal AcrySof IOLs is the most cost-saving treatment option for health care systems when compared to other acrylic single-piece IOLs.

摘要

目的

本研究的目的是评估在英国、意大利和丹麦的医疗环境中,掺钕钇铝石榴石(Nd:YAG)激光晶状体囊切开术及其因单片丙烯酸单焦点人工晶状体(IOL)引发的并发症所产生的成本影响。

材料与方法

建立了一个假设的成本后果模型,以估计不同单片丙烯酸单焦点IOL导致的Nd:YAG激光晶状体囊切开术的经济负担。白内障手术后3年使用五种单片单焦点丙烯酸IOL进行Nd:YAG激光晶状体囊切开术的累积发生率,源自英国白内障患者电子病历的回顾性数据分析。Nd:YAG激光术后并发症(即3年后视网膜脱离、青光眼和黄斑囊样水肿)的风险概率,通过已发表的文献得出。单位成本取自公开可用来源,所有成本均换算为欧元(€)。每个国家每年的白内障手术数量源自欧盟统计局的统计数据。

结果

对于每年在全国范围内估计进行的白内障手术,与其他单片单焦点丙烯酸IOL相比,单片单焦点疏水型AcrySof IOL在白内障手术后3年与Nd:YAG激光晶状体囊切开术及后续并发症的病例数大幅减少相关。在评估的国家中,使用AcrySof相对于其他IOL的总成本节省范围为0.5百万欧元至470万欧元(与AMO Tecnis相比)以及210万欧元至1790万欧元(与Rayner C-/Super-flex相比)。

结论

由于IOL选择导致的Nd:YAG晶状体囊切开术发生率,可能会对白内障手术后时期的医疗预算产生重大影响。我们的分析表明,与其他丙烯酸单片IOL相比,单片单焦点AcrySof IOL对医疗系统而言是最具成本效益的治疗选择。

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