Fan Jiahua, Liu Yangqing, Yin Songping, Chen Nixuan, Bai Xinxiu, Ke Qiuyi, Shen Jia, Xia Min
Guangdong Provincial Key Laboratory of Food, Nutrition and Health; Guangdong Engineering Technology Research Center of Nutrition Translation; Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), Guangzhou, Guangdong Province, People's Republic of China.
Nutr Metab (Lond). 2019 Jan 21;16:7. doi: 10.1186/s12986-019-0334-y. eCollection 2019.
Small dense LDL cholesterol (sdLDL-c) has been established to be highly associated with metabolic disorder. However, the relationship between circulating sdLDL-c and the presence of metabolic syndrome (MetS) has not been fully established.
A total of 1065 Chinese males (45.07 ± 11.08 years old) without diabetes and general obesity was recruited into a population-based, cross-sectional study. The MetS was defined based on the updated National Cholesterol Education Program/ Adult Treatment Panel III criteria for Asian Americans. Serum sdLDL-c concentration was measured by a homogeneous assay method and its relationship with MetS and its traits was investigated.
Serum sdLDL-c concentrations increased gradually with increasing numbers of MetS components ( < 0.001) and the proportion of patients with MetS increased gradually with increasing sdLDL-c levels ( for trend< 0.001). For the second, third, and fourth sdLDL-c quartiles versus the first, the OR (95% CI) for MetS were 4.47(2.41,8.28), 5.47(2.97,10.07) and 8.39(4.58,15.38) ( < 0.001 for trend) after multivariate adjustment. The stratified analysis conducted according to LDL-c levels showed that the OR between serum sdLDL-c levels and MetS was greater in those LDL-c levels lower than 3.3 mmol/L (OR = 22.97; 95% CI, 7.64-69.09) than in those LDL-c levels higher than 3.3 mmol/L (OR = 17.49; 95% CI, 4.43-68.98). Mediation analysis showed sdLDL-c mediated 38.6% of the association of waist circumference with triglycerides, while the association between sdLDL-c and MetS components did not mediate by hsCRP.
This study found that high sdLDL-c concentrations were associated with the presence of MetS independently of central obesity and inflammation.
小而密低密度脂蛋白胆固醇（sdLDL-c）已被证实与代谢紊乱高度相关。然而，循环sdLDL-c与代谢综合征（MetS）之间的关系尚未完全明确。
一项基于人群的横断面研究纳入了1065名无糖尿病和全身性肥胖的中国男性（45.07±11.08岁）。根据更新后的美国国家胆固醇教育计划/成人治疗小组III针对亚裔美国人的标准定义代谢综合征。采用均相测定法测量血清sdLDL-c浓度，并研究其与代谢综合征及其特征的关系。
血清sdLDL-c浓度随代谢综合征组分数量的增加而逐渐升高（P<0.001），且代谢综合征患者的比例随sdLDL-c水平的升高而逐渐增加（趋势P<0.001）。多因素调整后，与第一sdLDL-c四分位数相比，第二、第三和第四sdLDL-c四分位数的代谢综合征比值比（OR，95%可信区间）分别为4.47（2.41，8.28）、5.47（2.97，10.07）和8.39（4.58，15.38）（趋势P<0.001）。根据低密度脂蛋白胆固醇（LDL-c）水平进行的分层分析显示，LDL-c水平低于3.3 mmol/L者血清sdLDL-c水平与代谢综合征之间的OR（OR = 22.97；95%可信区间，7.64 - 69.09）高于LDL-c水平高于3.3 mmol/L者（OR =
