Lu Jieli, Wang Limin, Li Mian, Xu Yu, Jiang Yong, Wang Weiqing, Li Jianhong, Mi Shengquan, Zhang Mei, Li Yichong, Wang Tiange, Xu Min, Zhao Zhiyun, Dai Meng, Lai Shenghan, Zhao Wenhua, Wang Linhong, Bi Yufang, Ning Guang
State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.
National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
J Clin Endocrinol Metab. 2017 Feb 1;102(2):507-515. doi: 10.1210/jc.2016-2477.
In China, data on the prevalence of metabolic syndrome have been rare recently.
The objective of the study was to evaluate the prevalence of metabolic syndrome and its components in 2010.
DESIGN, SETTING, AND PARTICIPANTS: The study covered all 31 provinces of mainland China and consisted of a nationally representative population sample of 98,658 Chinese adults aged ≥18 years. Of these, 97,098 participants were eligible for the data analysis reported here.
Estimates of the prevalence of metabolic syndrome and its components were calculated. To further explore whether metabolic syndrome is associated with the 10-year coronary heart disease risk, sex-stratified logistic regression models were used.
The prevalence of the metabolic syndrome was 33.9% (31.0% in men and 36.8% in women), which indicates that metabolic syndrome affects approximately 454 million adults in China. More than half of total adult population was suffering from low high-density lipoprotein cholesterol (HDL-C), and nearly half of participants had high blood pressure. Abdominal obesity and low HDL-C were more prevalent in women than in men, whereas high blood pressure, high blood glucose, and high triglycerides were more common in men. Metabolic syndrome was associated with a higher 10-year coronary heart disease risk after adjustment for potential risk factors and each component of metabolic syndrome as continuous variables.
Our results showed a high prevalence of metabolic syndrome and its components in the general adult population in mainland China. Metabolic syndrome was independently associated with a higher 10-year risk of developing coronary heart disease.
在中国,近期关于代谢综合征患病率的数据较少。
本研究的目的是评估2010年代谢综合征及其组分的患病率。
设计、地点和参与者:该研究覆盖中国大陆所有31个省份,由98658名年龄≥18岁的具有全国代表性的中国成年人样本组成。其中,97098名参与者符合此处报告的数据分析条件。
计算代谢综合征及其组分患病率的估计值。为进一步探讨代谢综合征是否与10年冠心病风险相关,使用了按性别分层的逻辑回归模型。
代谢综合征的患病率为33.9%(男性为31.0%,女性为36.8%),这表明在中国约有4.54亿成年人受代谢综合征影响。超过一半的成年人口存在高密度脂蛋白胆固醇(HDL-C)降低,近一半的参与者患有高血压。腹部肥胖和HDL-C降低在女性中比在男性中更普遍,而高血压、高血糖和高甘油三酯在男性中更常见。在对潜在危险因素以及作为连续变量的代谢综合征各组分进行调整后,代谢综合征与10年冠心病风险较高相关。
我们的结果显示,中国大陆普通成年人群中代谢综合征及其组分的患病率较高。代谢综合征与10年发生冠心病的较高风险独立相关。