[婴儿自闭症的免疫状态。免疫状态、自闭症症状与血清素水平之间的相关性]

[Immune status in infantile autism. Correlation between the immune status, autistic symptoms and levels of serotonin].

作者信息

Ferrari P, Marescot M R, Moulias R, Bursztejn C, Deville Chabrolle A, Thiollet M, Lesourd B, Braconnier A, Dreux C, Zarifian E

机构信息

Service de Psychothérapie, l'Enfant et de l'Adolescent, Hôpital Robert Debré, Reims.

出版信息

Encephale. 1988 Sep-Oct;14(5):339-44.

PMID:3215138

Abstract

In sixteen autistic children high values of IgG and a high level of lymphocyte stimulation with PHA were observed. Principal component analysis showed: 1) a significant correlation between basic lymphocyte mitogenic activity and the clinical symptoms opposition and hyperactivity, 2) a significant correlation between high Ig levels, high PHA stimulation responses and the main autistic symptoms (withdrawal, inaffectivity, hypoactivity, mannerism, stereotypy and negatively echolalia), 3) a significant correlation with serotonin uptake by platelets and high immunological responses. Such correlations are strongly in favor of an immunologic component in autistic disease.

摘要

在16名自闭症儿童中，观察到IgG值较高以及PHA刺激淋巴细胞的水平较高。主成分分析显示：1）基础淋巴细胞促有丝分裂活性与临床症状对立和多动之间存在显著相关性；2）高Ig水平、高PHA刺激反应与主要自闭症症状（退缩、情感淡漠、活动减退、特殊姿势、刻板动作和消极模仿言语）之间存在显著相关性；3）与血小板对血清素的摄取和高免疫反应存在显著相关性。这些相关性强烈支持自闭症疾病中存在免疫成分。