Džubur Alen, Ejubović Malik, Fajkić Almir, Dervišević Amela, Durak Nalbantić Azra, Avdić Agić Ajla, Džubur Amela, Mekić Mevludin
Clinic for Heart Disease, Blood Vessels and Rheumatism, University Clinical Centre Sarajevo, Sarajevo, Bosnia and Herzegovina.
Department of Internal Diseases, Cantonal Hospital Zenica, Zenica, Bosnia and Herzegovina.
Med Glas (Zenica). 2019 Feb 1;16(1):28-34. doi: 10.17392/990-19.
Aim To assess triglyceride - to high-density lipoprotein cholesterol (TG/HDL)-C ratio in patients with acute coronary syndrome (ACS) and to verify its association with renal dysfunction. Methods A cross sectional study included 85 ACS patients divided in two groups with (ACS - RD) and without (ACS-nRD) presence of renal dysfunction, and 35 healthy subjects. Blood pressure, blood glucose, C-reactive protein, urea, creatinine, eGFR and serum lipids levels (total cholesterol, triglycerides, LDL-C, HDL-C) was measured in all participants. Based on the values of the measured lipid fractions TG/HDLc ratio was calculated. Results Patients in ACS group had significantly lower HDL-C level (p<0.0005) but significantly higher TG level (p=0.046) and TG/HDL-C ratio (p<0.0005) than controls. There was a significant increase (p<0.0005) in TG/HDL-C ratio in ACS-RD group compared to ACS-nRD group. The ACS-RD group had significantly higher level of TG (p=0.001), serum urea (p=0.02) and creatinine (p<0.0005) compared to the ACS-nRD group. With a cut-off level of 1.135 TG/HDL-C ratio had a sensitivity of 77.6% and a specificity of 62.9% in distinguishing between ACS patients and healthy subjects. With cut-off value of 1.905 TG/HDL-C ratio had a sensitivity of 75.9% and a specificity of 78.6% in distinguishing between ACS patients with and without renal dysfunction. Conclusion This study confirms the reliability of the TG/HDLC ratio as a simple, low cost and useful marker in distinguishing between patients with ACS and healthy subjects and ACS patients with and without renal dysfunction.
评估急性冠脉综合征（ACS）患者的甘油三酯与高密度脂蛋白胆固醇（TG/HDL）-C 比值，并验证其与肾功能不全的相关性。方法：一项横断面研究纳入了 85 例 ACS 患者，分为存在肾功能不全（ACS - RD）和不存在肾功能不全（ACS - nRD）的两组，以及 35 名健康受试者。测量了所有参与者的血压、血糖、C 反应蛋白、尿素、肌酐、估算肾小球滤过率（eGFR）和血脂水平（总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇）。根据测得的脂质组分值计算 TG/HDLc 比值。结果：ACS 组患者的高密度脂蛋白胆固醇水平显著低于对照组（p<0.0005），但甘油三酯水平显著高于对照组（p = 0.046），TG/HDL - C 比值也显著高于对照组（p<0.0005）。与 ACS - nRD 组相比，ACS - RD 组的 TG/HDL - C 比值显著升高（p<0.0005）。与 ACS - nRD 组相比，ACS - RD 组的甘油三酯水平（p = 0.001）、血清尿素水平（p = 0.02）和肌酐水平（p<0.0005）显著更高。当 TG/HDL - C 比值的截断值为 1.135 时，区分 ACS 患者和健康受试者的灵敏度为 77.6%，特异性为 62.9%。当 TG/HDL - C 比值的截断值为 1.905 时，区分有和没有肾功能不全的 ACS 患者的灵敏度为 75.9%，特异性为 78.6%。结论：本研究证实了 TG/HDL - C 比值作为一种简单、低成本且有用的标志物，在区分 ACS 患者与健康受试者以及有和没有肾功能不全的 ACS 患者方面的可靠性。
