Rogers Barbara B, Cuddahy Terri, Briscella Caralyn, Ross Nicole, Olszanski Anthony J, Denlinger Crystal S
Fox Chase Cancer Center.
Clin J Oncol Nurs. 2019 Feb 1;23(1):68-75. doi: 10.1188/19.CJON.68-75.
Oxaliplatin is used extensively for the treatment of gastrointestinal cancer and other malignancies, with increased frequency of use in recent years. Hypersensitivity reactions (HSRs) can pose a major problem in clinical practice because they can limit the use of oxaliplatin in the care of malignancies in which it has proven efficacy. Nurses play an integral role in the administration of oxaliplatin; therefore, they need to be well educated in the prevention, detection, and management of HSRs.
This article reviews the symptoms of HSRs associated with oxaliplatin, the specific management of HSRs associated with oxaliplatin, the role of desensitization, and the potential use of skin testing to better identify patients at risk for HSR.
This article reviews the literature related to the diagnosis, prevention, and management of HSRs associated with oxaliplatin and outlines nurses' role.
Oxaliplatin HSRs can occur at any cycle, but patients are at highest risk after they have received six prior infusions of oxaliplatin.
奥沙利铂广泛用于治疗胃肠道癌和其他恶性肿瘤，近年来使用频率不断增加。超敏反应（HSRs）在临床实践中可能构成重大问题，因为它们会限制奥沙利铂在已证明其疗效的恶性肿瘤治疗中的使用。护士在奥沙利铂的给药过程中起着不可或缺的作用；因此，他们需要在HSRs的预防、检测和管理方面接受良好的教育。
本文综述了与奥沙利铂相关的HSRs症状、与奥沙利铂相关的HSRs的具体管理、脱敏的作用以及皮肤试验在更好地识别HSR风险患者方面的潜在用途。
本文综述了与奥沙利铂相关的HSRs的诊断、预防和管理的相关文献，并概述了护士的作用。
奥沙利铂HSRs可在任何周期发生，但患者在先前接受六次奥沙利铂输注后风险最高。
