Colburn W A
Pharmacokinetics/Drug Metabolism Department, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan 48105.
J Clin Pharmacol. 1988 Sep;28(9):769-71. doi: 10.1002/j.1552-4604.1988.tb03215.x.
Several compartmental and noncompartmental approaches have been successfully applied to PK/PD modeling. Although great opportunities exist to expand on these techniques, application of these methods to relate concentrations of all drugs to their effects is possible.