[Muscle metabolic state in tourniquet syndrome in the rat after administration of the proteinase inhibitor aprotinin (author's transl)].

The metabolic status of rat skeletal muscle was examined after 5 h of unilateral ischemia of one hind leg and following 5 h of recirculation. There was no recovery, neither with nor without aprotinin (Trasylol) in different doses (35 000 and 125 000 KIE/kg b.w.). After 3 h of ischemia and 3 h of recirculation a significant recovery of the metabolic status occurred in animals without and with 35 000 KIE aprotinin/kg b.w. After injection of 125 000 KIE aprotinin the restoration of the metabolic status was significantly retarded. The metabolic situation of the contralateral, non-ischemic legs revealed--in comparison to normal levels--a significant deterioration in the latter group.