Molzberger H, Heugel E, Isselhard W
Arzneimittelforschung. 1978;28(3):394-7.
The metabolic status of rat skeletal muscle was examined after 5 h of unilateral ischemia of one hind leg and following 5 h of recirculation. There was no recovery, neither with nor without aprotinin (Trasylol) in different doses (35 000 and 125 000 KIE/kg b.w.). After 3 h of ischemia and 3 h of recirculation a significant recovery of the metabolic status occurred in animals without and with 35 000 KIE aprotinin/kg b.w. After injection of 125 000 KIE aprotinin the restoration of the metabolic status was significantly retarded. The metabolic situation of the contralateral, non-ischemic legs revealed--in comparison to normal levels--a significant deterioration in the latter group.
在单侧后肢缺血5小时及再灌注5小时后，对大鼠骨骼肌的代谢状态进行了检查。无论是否使用不同剂量（35000和125000激肽释放酶抑制单位/千克体重）的抑肽酶（胰蛋白酶抑制剂），均未出现恢复情况。在缺血3小时和再灌注3小时后，未注射抑肽酶以及注射35000激肽释放酶抑制单位/千克体重抑肽酶的动物，其代谢状态出现了显著恢复。注射125000激肽释放酶抑制单位抑肽酶后，代谢状态的恢复明显延迟。与正常水平相比，后一组中对侧未缺血腿的代谢状况出现了显著恶化。
