妇科肿瘤的个体化医学：事实还是虚构？
Personalized Medicine in Gynecologic Cancer: Fact or Fiction?
机构信息
Department of Obstetrics and Gynecology, Ochsner Clinic Foundation, 2700 Napoleon Avenue, New Orleans, LA 70115, USA.
Department of Obstetrics and Gynecology, Ochsner Clinic Foundation, 2700 Napoleon Avenue, New Orleans, LA 70115, USA.
出版信息
Obstet Gynecol Clin North Am. 2019 Mar;46(1):155-163. doi: 10.1016/j.ogc.2018.09.010.
Personalized medicine in gynecologic oncology is an evolving field. In recent years, tumor profiling and large databases such as TCGA and NCI-Match have provided us with enormous amounts of molecular data. Several therapies that capitalize on novel genetic and immune discoveries including VEGF inhibitors, PARP inhibitors, and cancer vaccinations are discussed in this article. Additionally, we have seen direct to consumer marketing play an important role in cancer care and prevention as patients have increased ability to access genetic testing. This presents a unique challenge to gynecologic oncology providers as we learn to navigate the world of personalized medicine.
妇科肿瘤学中的个性化医学是一个不断发展的领域。近年来，肿瘤分析和 TCGA 和 NCI-Match 等大型数据库为我们提供了大量的分子数据。本文讨论了几种利用新型遗传和免疫发现的疗法，包括 VEGF 抑制剂、PARP 抑制剂和癌症疫苗。此外，我们已经看到直接面向消费者的营销在癌症护理和预防中发挥了重要作用，因为患者越来越有能力进行基因检测。这给妇科肿瘤学提供者带来了独特的挑战，因为我们要学习如何驾驭个性化医学的世界。
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