Xu He-Huan, Song Jinshuai, Xu Hai-Chao
State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, P.R. China.
College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, P.R. China.
ChemSusChem. 2019 Jul 5;12(13):3060-3063. doi: 10.1002/cssc.201803058. Epub 2019 Feb 25.
Electrochemical 1,2-hydroxydifluoromethylation and C-H difluoromethylation of acrylamides were developed by using CF HSO NHNHBoc as the source of the CF H group. These electricity-powered oxidative alkene functionalization reactions do not need transition-metal catalysts or chemical oxidants. The reaction outcome, 1,2-difuntionalization or C-H functionalization, is determined by the substituents on the amide nitrogen atom of the acrylamides instead of by the reaction conditions.
通过使用CFHSO2NHNHBoc作为CFH基团的来源，实现了丙烯酰胺的电化学1,2-羟基二氟甲基化和C-H二氟甲基化。这些电力驱动的氧化烯烃官能化反应不需要过渡金属催化剂或化学氧化剂。反应结果，即1,2-双官能化或C-H官能化，由丙烯酰胺酰胺氮原子上的取代基决定，而不是由反应条件决定。
