Yang Xu-Heng, Wei Wen-Ting, Li Hai-Bing, Song Ren-Jie, Li Jin-Heng
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
Chem Commun (Camb). 2014 Nov 4;50(85):12867-9. doi: 10.1039/c4cc05051g.
A new oxidative coupling of unactivated terminal alkenes with amides using peroxides is described, in which mono- and difunctionalization of alkenes are selectively achieved. In this reaction with amides, the chemoselectivity toward the functionalization of the C(sp(3))-H bonds adjacent to the nitrogen atom or the functionalization of the carbonyl C(sp(2))-H bonds across alkenes relies on the reaction conditions.
本文描述了一种使用过氧化物实现未活化末端烯烃与酰胺的新型氧化偶联反应，该反应能选择性地实现烯烃的单官能化和双官能化。在与酰胺的此反应中，对于与氮原子相邻的C(sp(3))-H键官能化或跨烯烃的羰基C(sp(2))-H键官能化的化学选择性取决于反应条件。
