Bezrukov Vladyslav V, Bachinskaya Natalia Yu, Kopchak Oksana O, Kholin Victor O, Pulyk Oleksandr R
Department of Age Physiology And Pathology of The Nervous System, D.F. Chebotarev Institute Of Gerontology of National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine.
Department of Age Physiology And Pathology of The Nervous System, D.F. Chebotarev Institute Of Gerontology of National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine Department of Neurology, Kyiv Medical University, Kyiv, Ukraine.
Wiad Lek. 2018;71(8):1515-1523.
Introduction: According to World Health Organization (WHO) forecasts, by 2050 the number of people suffering from dementia will constitute about 150 millions in the world. Nowadays, Alzheimer's disease plays the leading role in dementia emergence; it is the cause of age related dementia in 60% of cases. The aim: This study aimed to assess the age related cognitive changes in patients with metabolic syndrome (MetS).
Materials and methods: 503 patients aged 45 to 89 years with chronic cerebral ischemia were included into the study. All the patients were divided into two groups: group 1 - without MetS (n = 198), group 2 - with MetS (n = 305). Patients of both groups were divided into 3 age subgroups: 1st - 45-59, 2nd - 60-74, 3rd - 75-89 years old.The MetS was defined according to the criteria of the American Heart Association, the World Heart Federation, the International Atherosclerosis Society, and the International Association for the Study of Obesity. To evaluate patients' cognitive functions wide range of neuropsychological tests were used.
Results: Patients of both groups had significant age related cognitive deficit. MetS patients of all age subgroups with mild cognitive impairment syndrome revealed a significant decline of immediate and delayed memory on the verbal stimuli (especially in patients of elderly and senior age groups), the rate of sensorimotor reactions, mental capacity, and the active attention amount in comparison to the patients without MetS. MetS patients with dementia of the middle age had significantly lower parameters of immediate and delayed memory on the verbal stimuli, the rate of sensorimotor reactions, mental capacity, and the active attention amount in comparison to the patients without MetS but with dementia.
Conclusions:The presence of MetS was associated with more pronounced cognitive decline in the patients, concerning different aspects of memory, attention and executive functions.
引言：根据世界卫生组织（WHO）的预测，到2050年，全球患有痴呆症的人数将达到约1.5亿。如今，阿尔茨海默病在痴呆症的发病中起主导作用；它是60%与年龄相关的痴呆症的病因。目的：本研究旨在评估代谢综合征（MetS）患者与年龄相关的认知变化。
材料与方法：纳入503例年龄在45至89岁的慢性脑缺血患者进行研究。所有患者分为两组：第1组 - 无代谢综合征（n = 198），第2组 - 有代谢综合征（n = 305）。两组患者又分为3个年龄亚组：第1组 - 45 - 59岁，第2组 - 60 - 74岁，第3组 - 75 - 89岁。代谢综合征根据美国心脏协会、世界心脏联合会、国际动脉粥样硬化学会和国际肥胖研究协会的标准定义。为评估患者的认知功能，使用了广泛的神经心理学测试。
结果：两组患者均有明显的与年龄相关的认知缺陷。与无代谢综合征的患者相比，所有年龄亚组患有轻度认知障碍综合征的代谢综合征患者在言语刺激下的即时和延迟记忆（尤其是老年和高龄组患者）、感觉运动反应速度、心理能力和主动注意力均有显著下降。与无代谢综合征但患有痴呆症的患者相比，中年患有痴呆症的代谢综合征患者在言语刺激下的即时和延迟记忆参数、感觉运动反应速度、心理能力和主动注意力均显著降低。
结论：代谢综合征的存在与患者在记忆、注意力和执行功能的不同方面更明显的认知衰退有关。
