Department of Bioorganic Chemistry, Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89b, 61‒614 Poznań, Poland.
Bob Champion Research & Education Building, Norwich Medical School, University of East Anglia, Norwich, UK.
Eur J Med Chem. 2019 Mar 15;166:32-47. doi: 10.1016/j.ejmech.2019.01.035. Epub 2019 Jan 17.
Despite some progress in recent years, the fight against parasitic diseases still remains a great challenge. Parasitic diseases affect primarily (but not exclusively) the poorest people living in underdeveloped regions of the world. The distribution of parasitoses are linked to tropical and subtropical climate conditions, to population growth and to impoverishment. If not treated, parasitic diseases may lead to serious health problems, and even death. Particularly vulnerable groups include infants and young children, pregnant women and immunocompromised individuals. Polyether ionophore antibiotics (ionophores), traditionally used in veterinary medicine as anti-coccidial feed additives and non-hormonal growth promoters, are of considerable interest, as they have been found to be highly effective agents against various parasites, both in vitro and in vivo. This review summarizes the anti-parasitic effects of the most important polyether ionophores against parasites that are responsible for a number of animal and human parasitic diseases. Recent findings and advances that support the potential of polyether ionophore antibiotics as novel anti-parasitic drug candidates are also presented and discussed.
尽管近年来取得了一些进展，但抗击寄生虫病仍然是一个巨大的挑战。寄生虫病主要影响（但不仅限于）生活在世界欠发达地区的最贫困人口。寄生虫病的分布与热带和亚热带气候条件、人口增长和贫困化有关。如果不加以治疗，寄生虫病可能导致严重的健康问题，甚至死亡。特别脆弱的群体包括婴儿和幼儿、孕妇和免疫功能低下者。聚醚离子载体抗生素（离子载体）在兽医中传统上用作抗球虫饲料添加剂和非激素生长促进剂，具有相当大的兴趣，因为它们已被发现对各种寄生虫具有高度有效的作用，无论是在体外还是体内。本文综述了最重要的聚醚离子载体对寄生虫的抗寄生虫作用，这些寄生虫导致了许多动物和人类寄生虫病。还介绍和讨论了支持聚醚离子载体抗生素作为新型抗寄生虫药物候选物的潜在作用的最新发现和进展。
