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急性淋巴细胞白血病（ALL）中酶细胞化学结果与免疫标志物检测的比较。

Comparison of enzyme-cytochemical findings and immunological marker investigations in acute lymphatic leukemia (ALL).

作者信息

Andreewa P, Huhn D, Thiel E, Rodt H

出版信息

Blut. 1978 May 18;36(5):299-305. doi: 10.1007/BF01880680.

DOI:10.1007/BF01880680
PMID:306849
Abstract

APh-activity and PAS-positive deposits were studied in 50 cases of ALL, classified as T-ALL and O-ALL according to immunological marker investigations. Correlation between morphological features of the cells and APh and PAS reactions, as well as between morphology and immunological markers was not detected. APh-activity in general was stronger in T-ALL (R+ and R-), while PAS-content was more pronounced in O-ALL. The results suggest that cytochemical methods, especially APh and PAS reaction, are valuable to distinguish T-ALL from O-ALL but not reliable enough to replace immunological marker investigations.

摘要

对50例急性淋巴细胞白血病（ALL）患者进行了酸性磷酸酶（APh）活性和过碘酸雪夫（PAS）阳性沉积物的研究，根据免疫标志物检测将其分为T细胞急性淋巴细胞白血病（T-ALL）和普通型急性淋巴细胞白血病（O-ALL）。未检测到细胞形态特征与APh和PAS反应之间以及形态与免疫标志物之间的相关性。总体而言，T-ALL（R+和R-）中的APh活性更强，而O-ALL中的PAS含量更明显。结果表明，细胞化学方法，尤其是APh和PAS反应，对于区分T-ALL和O-ALL有价值，但不足以可靠地取代免疫标志物检测。

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1
Comparison of enzyme-cytochemical findings and immunological marker investigations in acute lymphatic leukemia (ALL).急性淋巴细胞白血病（ALL）中酶细胞化学结果与免疫标志物检测的比较。
Blut. 1978 May 18;36(5):299-305. doi: 10.1007/BF01880680.
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引用本文的文献

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3
Differential diagnostic value of acid phosphatase and beta-glucuronidase in acute leukaemia.酸性磷酸酶和β-葡萄糖醛酸酶在急性白血病中的鉴别诊断价值

本文引用的文献

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SIMPLIFIED MYELOPEROXIDASE STAIN USING BENZIDINE DIHYDROCHLORIDE.使用盐酸联苯胺的简化髓过氧化物酶染色法。
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Acta Haematol. 1976;56(3):129-36. doi: 10.1159/000207929.
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Quantitation of T-antigenic sites and Ig-determinants on leukemic cells by microphotometric immunoautoradiography. Proof of the clonal origin of thymus-derived lymphocytic leukemias.
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Classification of leukemic cells with T- and O-ALL-specific antisera.使用T-ALL和O-ALL特异性抗血清对白血病细胞进行分类。
Haematol Blood Transfus. 1977;20:87-96. doi: 10.1007/978-3-642-66639-1_9.