Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
Division of Biostatistics, Department of Data Management, Center for Clinical Research, National Center for Child Health and Development, Tokyo, Japan.
J Thorac Cardiovasc Surg. 2019 Jul;158(1):61-69.e4. doi: 10.1016/j.jtcvs.2018.11.103. Epub 2018 Dec 14.
This study aimed to assess the predictors of patient-prosthesis mismatch (PPM) after surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR) using preoperative computed tomography.
We enrolled 323 patients undergoing SAVR (n = 85) or TAVR (n = 238) for aortic stenosis. The end point was any degree of PPM (effective orifice area index <0.85 cm/m). We assessed the predictors of PPM after SAVR or TAVR and compared the incidence of PPM between both arms. Furthermore, we compared the hemodynamic performance using the propensity score matching.
The occurrence of PPM was significantly higher in the SAVR arm (24.7% vs 7.1%; P < .001). A small sinotubular junction was an independent predictor of PPM in the SAVR arm (odds ratio, 0.79; 95% confidence interval, 0.65-0.96; P = .015), but not a significant predictor in the TAVR arm. In patients with a small sinotubular junction, the prevalence of PPM in the SAVR arm was higher (57.9% vs 2.9%; P < .001). Furthermore, among the propensity score-matched patients, the incidence of PPM in the SAVR arm was higher than that in the TAVR arm (26.3% vs 12.5%; P = .031).
In patients with a small sinotubular junction detected by preoperative computed tomography assessment, the incidence of PPM in patients undergoing SAVR was higher.
本研究旨在通过术前计算机断层扫描评估外科主动脉瓣置换术(SAVR)或经导管主动脉瓣置换术(TAVR)后患者-假体不匹配(PPM)的预测因素。
我们纳入了 323 名接受主动脉瓣狭窄治疗的患者,包括 SAVR(n=85)或 TAVR(n=238)。终点是任何程度的 PPM(有效瓣口面积指数<0.85 cm/m)。我们评估了 SAVR 或 TAVR 后 PPM 的预测因素,并比较了两臂之间 PPM 的发生率。此外,我们使用倾向评分匹配比较了血液动力学性能。
SAVR 组 PPM 的发生率明显更高(24.7%比 7.1%;P<0.001)。小窦管交界是 SAVR 组 PPM 的独立预测因素(比值比,0.79;95%置信区间,0.65-0.96;P=0.015),但不是 TAVR 组的显著预测因素。在小窦管交界的患者中,SAVR 组 PPM 的患病率更高(57.9%比 2.9%;P<0.001)。此外,在倾向评分匹配的患者中,SAVR 组 PPM 的发生率高于 TAVR 组(26.3%比 12.5%;P=0.031)。
在术前计算机断层扫描评估发现小窦管交界的患者中,SAVR 后 PPM 的发生率较高。