Neonatal Research Unit, Health Research Institute La Fe, Valencia, Spain.
Neurology Unit, University and Polytechnic Hospital La Fe, Valencia, Spain.
Clin Chim Acta. 2019 Apr;491:85-90. doi: 10.1016/j.cca.2019.01.021. Epub 2019 Jan 24.
Alzheimer's disease (AD), the most common form of dementia, has tremendous social and economic impact worldwide. Research has shown an association between pathologic development of AD and increased free-radical production. As such, the role of peroxidation in brain lipid damage and AD progression has received special attention. Previous studies on lipid peroxidation have improved our understanding of the unique pathophysiologic processes involved in AD. These studies have also served to identify potentially new biomarkers including lipid peroxidation metabolites for diagnosis, prognosis and therapy. Unfortunately, these putative markers have generated controversial results and further research, especially early stage AD, is clearly warranted. The aim of this paper is to review the usefulness of lipid peroxidation biomarkers in AD diagnosis and prognosis as well as monitoring disease development and therapeutic treatment thereof.
阿尔茨海默病（AD）是最常见的痴呆症形式，在全球范围内具有巨大的社会和经济影响。研究表明，AD 的病理发展与自由基产生增加之间存在关联。因此，过氧化作用在脑脂质损伤和 AD 进展中的作用受到了特别关注。先前关于脂质过氧化的研究提高了我们对 AD 中涉及的独特病理生理过程的理解。这些研究还有助于确定潜在的新生物标志物，包括脂质过氧化代谢物，用于诊断、预后和治疗。不幸的是，这些推测的标志物产生了有争议的结果，显然需要进一步研究，特别是在早期 AD 阶段。本文的目的是综述脂质过氧化生物标志物在 AD 诊断和预后以及监测疾病发展和治疗中的有用性。
