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中国蒙古族人群中HLA-DRB1、DPB1和DQB1等位基因及单倍型的分布

Distribution of HLA-DRB1, DPB1 and DQB1 alleles and haplotypes in Mongolian Minority in China.

作者信息

Gu Qin, Chen Jun, Yao Yufeng, Sun Mingbo, Shi Li

机构信息

Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China; Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Disease, Kunming, China.

Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China.

出版信息

Hum Immunol. 2019 Apr;80(4):215-217. doi: 10.1016/j.humimm.2019.01.006. Epub 2019 Jan 24.

DOI:10.1016/j.humimm.2019.01.006
PMID:30685398
Abstract

HLA-DRB1, -DQB1 and -DPB1 allele frequencies and estimated haplotype frequencies from 496 unrelated healthy Mongol subjects who living in Inner Mongolia Autonomous Region of China has been reported. HLA genes were genotyped using high-resolution sequence-based typing method. Chinese-Mongolian belongs to northern group of East Asians, but with its specific HLA-DRB1, DPB1 and DQB1 alleles and haplotypes characteristic.

摘要

已报道了来自生活在中国内蒙古自治区的496名无亲缘关系健康蒙古族受试者的HLA-DRB1、-DQB1和-DPB1等位基因频率以及估计的单倍型频率。采用基于序列的高分辨率分型方法对HLA基因进行基因分型。中国蒙古族属于东亚北方群体,但具有其特定的HLA-DRB1、DPB1和DQB1等位基因及单倍型特征。

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