Cognitive Neurology Research Group, University of Exeter Medical School, Exeter, UK; Discipline of Psychology, University of Exeter, Exeter, UK.
Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
J Neuroimmunol. 2019 Feb 15;327:41-43. doi: 10.1016/j.jneuroim.2019.01.011. Epub 2019 Jan 22.
Transient Epileptic Amnesia (TEA) is a subtype of temporal lobe epilepsy, typically presenting in a person's early 60s, and of unknown aetiology. Encephalitis caused by antibodies to NMDA receptors (NMDARE) has not previously been documented in TEA. We describe a 47-year-old male who satisfied criteria for TEA, but given his atypical symptoms, was also screened for autoimmune epilepsy. High levels of serum NMDAR antibodies were found, suggesting NMDARE. Immunosuppressive treatment gradually eliminated the NMDA receptor antibodies. Our case extends the clinical spectrum associated with neuronal cell-surface autoantibodies to include atypical cases of TEA.
短暂性癫痫性遗忘症（TEA）是颞叶癫痫的一种亚型，通常发生在 60 岁出头的人群中，病因不明。NMDA 受体（NMDARE）抗体引起的脑炎以前没有在 TEA 中记录过。我们描述了一名 47 岁的男性，他符合 TEA 的标准，但由于他的症状不典型，也被筛查自身免疫性癫痫。发现血清 NMDAR 抗体水平升高，提示 NMDARE。免疫抑制治疗逐渐消除了 NMDA 受体抗体。我们的病例将与神经元细胞表面自身抗体相关的临床谱扩展到包括不典型的 TEA 病例。
