促进大脑衰老健康的策略。
Health-Promoting Strategies for the Aging Brain.
机构信息
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles; the University of California, Los Angeles, Longevity Center, Los Angeles; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles.
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles; the University of California, Los Angeles, Longevity Center, Los Angeles; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles.
出版信息
Am J Geriatr Psychiatry. 2019 Mar;27(3):213-236. doi: 10.1016/j.jagp.2018.12.016. Epub 2018 Dec 18.
As the world's population ages and people live longer, the changes in the aging brain present substantial challenges to our health and society. With greater longevity come age-related diseases, many of which have direct and indirect influences on the health of the brain. Although there is some degree of predictable decline in brain functioning with aging, meaningful cognitive decline is not inevitable and is perhaps preventable. In this review, we present the case that the course of aging-related brain disease and dysfunction can be modified. We present the evidence for conditions and risk factors that may contribute to cognitive decline and dementia and for interventions that may mitigate their impact on cognitive functioning later in life, or even prevent them and their cognitive sequelae from developing. Although much work remains to be done to meet the challenges of the aging brain, strategies to promote its health have been demonstrated and offer much promise, which can only be realized if we mount a vigorous public health effort to implement these strategies.
随着世界人口老龄化和人们寿命的延长，衰老大脑的变化给我们的健康和社会带来了巨大的挑战。随着寿命的延长，与年龄相关的疾病也随之而来，其中许多疾病对大脑健康有直接和间接的影响。虽然大脑功能随年龄增长会有一定程度的可预测性下降，但认知能力的显著下降并非不可避免，甚至可能是可以预防的。在这篇综述中，我们提出了这样一种观点，即与年龄相关的大脑疾病和功能障碍的进程是可以改变的。我们提出了可能导致认知能力下降和痴呆的情况和风险因素的证据，以及可能减轻其对晚年认知功能影响的干预措施，甚至预防它们及其认知后果的发展。尽管为了应对大脑衰老的挑战，还有很多工作要做，但促进大脑健康的策略已经得到了证明，并具有很大的前景，如果我们大力开展公共卫生工作来实施这些策略，这些前景才能实现。
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