Li Fan, Yu Rong Pei, Sun Dan, Wang Ji Hua, Li Shen Chong, Ruan Ji Wei, Shan Qin Li, Lu Ping Li, Wang Guo Xian
Flower Research Institute, Yunnan Academy of Agricultural Sciences, National Engineering Research Center for Ornamental Horticulture, Yunnan Key Laboratory for Flower Breeding, Kunming 650200, China.
Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China.
Yi Chuan. 2019 Jan 20;41(1):52-65. doi: 10.16288/j.yczz.18-165.
Meiotic recombination not only ensures the stability of chromosome numbers during the sexual reproduction in eukaryotes, but also shuffles the maternal and paternal genetic materials to generate genetic diversity in the gametes. Therefore, meiotic recombination is an important pathway for genetic diversity, which has been considered as a major driving force for species evolution and biodiversity in nature. In most eukaryotes, meiotic recombination is strictly limited, despite the large variation of physical genome size and chromosome numbers among species, but the mechanisms suppressing meiotic recombination remain elusive. Recently, several suppressors have been identified through the forward genetics screen, and revealed the functions and regulation pathways of these suppressors. In this review, we summarize the breakthrough discovery of meiotic recombination suppressors in plants based on research in Arabidopsis, with particular focus on the gene function and its regulation network to elucidate the molecular mechanisms of meiotic recombination suppression in plants.
减数分裂重组不仅确保了真核生物有性生殖过程中染色体数目的稳定性，还能使母本和父本的遗传物质重新组合，从而在配子中产生遗传多样性。因此，减数分裂重组是遗传多样性的重要途径，被认为是自然界物种进化和生物多样性的主要驱动力。在大多数真核生物中，尽管物种间物理基因组大小和染色体数目差异很大，但减数分裂重组受到严格限制，然而抑制减数分裂重组的机制仍不清楚。最近，通过正向遗传学筛选鉴定出了几种抑制因子，并揭示了这些抑制因子的功能和调控途径。在这篇综述中，我们基于拟南芥的研究总结了植物减数分裂重组抑制因子的突破性发现，特别关注基因功能及其调控网络，以阐明植物减数分裂重组抑制的分子机制。
