Suppr超能文献

布基纳法索的表达与HIV-1感染

expression and HIV-1 infection in Burkina Faso.

作者信息

Compaore Tegwinde Rebeca, Soubeiga Serge Theophile, Ouattara Abdoul Karim, Tchelougou Damehan, Bisseye Cyrille, Bakouan Didier Romuald, Compaore Issaka, Dembele Augustine, Yonli Albert Theophane, Obiri-Yeboah Dorcas, Djigma Wendkuuni Florencia, Simpore Jacques

机构信息

Pietro Annigoni Biomolecular Research Centre (CERBA)/LABIOGENE, University of Ouagadougou, Burkina Faso.

Permanent Secretary Against Aids and Sexually Transmitted Diseases, Ouagadougou, Burkina Faso.

出版信息

J Public Health Afr. 2018 Dec 21;9(3):907. doi: 10.4081/jphia.2018.907.

Abstract

APOBEC3G is a potent inhibitor of HIV-1 replication, and act by deaminating cytidines in uracil on the negative strand of the viral cDNA. In this case-control study, expression in subjects' naïve to HAART infected by HIV-1 and the effect of APOBEC3G polymorphism on its expression were evaluated. The results show that the HIV-1 infected carriers of the G minor alleles of the variant rs8177832 had a higher expression of mRNA than the controls carriers of the G minor allele. polymorphisms could play an important role in the modulation of the HIV-1 dissemination.

摘要

载脂蛋白B mRNA编辑酶催化多肽样蛋白3G(APOBEC3G)是HIV-1复制的有效抑制剂,其作用机制是使病毒互补DNA(cDNA)负链上的胞嘧啶脱氨基成为尿嘧啶。在这项病例对照研究中,评估了初治接受高效抗逆转录病毒治疗(HAART)的HIV-1感染者中APOBEC3G的表达情况以及APOBEC3G基因多态性对其表达的影响。结果显示,rs8177832变异位点G等位基因的HIV-1感染携带者的信使核糖核酸(mRNA)表达高于该G等位基因的对照携带者。基因多态性可能在HIV-1传播的调控中发挥重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b37c/6326155/c5b01089b762/jpha-9-3-907-g001.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验