布基纳法索的表达与HIV-1感染

expression and HIV-1 infection in Burkina Faso.

作者信息

Compaore Tegwinde Rebeca, Soubeiga Serge Theophile, Ouattara Abdoul Karim, Tchelougou Damehan, Bisseye Cyrille, Bakouan Didier Romuald, Compaore Issaka, Dembele Augustine, Yonli Albert Theophane, Obiri-Yeboah Dorcas, Djigma Wendkuuni Florencia, Simpore Jacques

机构信息

Pietro Annigoni Biomolecular Research Centre (CERBA)/LABIOGENE, University of Ouagadougou, Burkina Faso.

Permanent Secretary Against Aids and Sexually Transmitted Diseases, Ouagadougou, Burkina Faso.

出版信息

J Public Health Afr. 2018 Dec 21;9(3):907. doi: 10.4081/jphia.2018.907.

DOI:10.4081/jphia.2018.907

PMID:30687488

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6326155/

Abstract

APOBEC3G is a potent inhibitor of HIV-1 replication, and act by deaminating cytidines in uracil on the negative strand of the viral cDNA. In this case-control study, expression in subjects' naïve to HAART infected by HIV-1 and the effect of APOBEC3G polymorphism on its expression were evaluated. The results show that the HIV-1 infected carriers of the G minor alleles of the variant rs8177832 had a higher expression of mRNA than the controls carriers of the G minor allele. polymorphisms could play an important role in the modulation of the HIV-1 dissemination.

摘要

载脂蛋白B mRNA编辑酶催化多肽样蛋白3G（APOBEC3G）是HIV-1复制的有效抑制剂，其作用机制是使病毒互补DNA（cDNA）负链上的胞嘧啶脱氨基成为尿嘧啶。在这项病例对照研究中，评估了初治接受高效抗逆转录病毒治疗（HAART）的HIV-1感染者中APOBEC3G的表达情况以及APOBEC3G基因多态性对其表达的影响。结果显示，rs8177832变异位点G等位基因的HIV-1感染携带者的信使核糖核酸（mRNA）表达高于该G等位基因的对照携带者。基因多态性可能在HIV-1传播的调控中发挥重要作用。