Li Shuning, Jiang Jing, Yang Yiquan, Wu Gewei, Li Shi-Ming, Thomas Ravi, Wang Ningli
Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology & Visual Science Key Lab, Capital Medical University, Beijing, China.
Fushun Eye Hospital, Fushun, China.
J Ophthalmol. 2018 Dec 27;2018:8058951. doi: 10.1155/2018/8058951. eCollection 2018.
To determine the range of pupil size that has the largest iris volume in normal eyes.
31 healthy adult Chinese volunteers underwent swept-source anterior segment OCT examination in both eyes. Pilocarpine 1% was instilled in a randomly selected eye (eye with induced miosis (ME)) of each participant to obtain iris volume (IV) measurements over a range of pupil sizes. OCT was performed prior to and one hour after pilocarpine in both ME and fellow eye (FE). Iris volume (IV), anterior chamber volume (ACV), anterior chamber depth (ACD), and pupil size (PS) were recorded. A scatter plot was used to depict the association between each pupil size and IV.
The pupillary sizes for which IV was recorded in ME and FE ranged from 1.161 mm to 6.665 mm. The mean IV increased with miosis in both ME and FE; in 13 eyes, IV decreased with a decrease in pupillary size. PS between 3.812 and 6.665 mm was associated with an increase in IV, while PS between 3.159 and 5.54 mm was associated with a decrease. The relationship between PS and IV was in the shape of a downward parabola and was modeled using a quadratic equation ( = -1.3121 + 8.8429 + 16.423, = 0.26886). The largest IV occurred at PS between 3 and 4 mm.
The relationship between PS and IV in this study was in the shape of a downward parabola. The largest IV was recorded at a pupillary size between 3 and 4 mm. This trial is registered with ChiCTR-ROC-17013572.
确定正常眼睛中虹膜体积最大时的瞳孔大小范围。
31名健康成年中国志愿者双眼接受扫频源眼前节光学相干断层扫描（OCT）检查。在每位参与者随机选择的一只眼睛（诱导瞳孔缩小的眼睛（ME））中滴入1%毛果芸香碱，以获取一系列瞳孔大小下的虹膜体积（IV）测量值。在ME和对侧眼（FE）中，分别在滴入毛果芸香碱之前和之后1小时进行OCT检查。记录虹膜体积（IV）、前房体积（ACV）、前房深度（ACD）和瞳孔大小（PS）。使用散点图描绘每个瞳孔大小与IV之间的关联。
在ME和FE中记录IV时的瞳孔大小范围为1.161毫米至6.665毫米。ME和FE中，平均IV均随瞳孔缩小而增加；在13只眼中，IV随瞳孔大小减小而降低。3.812至6.665毫米之间的PS与IV增加相关，而3.159至5.54毫米之间的PS与IV降低相关。PS与IV之间的关系呈向下抛物线形状，并使用二次方程（ = -1.3121 + 8.8429 + 16.423， = 0.26886）进行建模。最大IV出现在3至4毫米的PS时。
本研究中PS与IV之间的关系呈向下抛物线形状。最大IV记录在瞳孔大小为3至4毫米时。本试验在中国临床试验注册中心注册，注册号为ChiCTR-ROC-17013572。
