Huang Jingjing, Wang Zhonghao, Wu Ziqiang, Li Zuohong, Lai Kunbei, Ge Jian
*State Key Laboratory of Ophthalmology, Department of Glaucoma, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China †Center for Advanced Eye Care, Carson City, NV.
J Glaucoma. 2015 Apr-May;24(4):323-7. doi: 10.1097/IJG.0b013e31829e55cd.
To compare the eye with chronic primary angle-closure glaucoma (CPACG) with its fellow eye without glaucoma damage and to determine the biometric differences that may predispose to development of CPACG.
Consecutive patients diagnosed with CPACG in 1 eye and primary angle-closure (PAC)/primary angle-closure suspected (PACS) in the fellow eye were recruited. The biometric parameters of both the eyes were measured by A-scan ultrasonic biometry and ultrasound biomicroscopy. Comparisons of visual function, baseline intraocular pressure (IOP), and the biometric measurements were made.
Forty-one patients were recruited. Eyes with CPACG had worse visual function, higher baseline IOP, and larger cup-to-disc ratio than their fellow eyes with PAC/PACS (P<0.001). Eyes with CPACG had shallower anterior chamber depths, smaller anterior chamber angles, thinner irises, and longer iris-ciliary process distances than their fellow eyes with PAC/PACS (P<0.05). There were no significant differences in terms of lens thicknesses, axial lengths, lens vault, and trabecular-ciliary process distances.
Lens thickness, lens location, and axial length do not appear to play a significant role in the progression from PAC/PACS to CPACG. A thin and anterior iris bowing may be related to the progression from PAC/PACS to CPACG.
比较患慢性原发性闭角型青光眼（CPACG）的眼与未受青光眼损害的对侧眼，确定可能易患CPACG的生物测量差异。
招募一眼被诊断为CPACG且对侧眼为原发性房角关闭（PAC）/疑似原发性房角关闭（PACS）的连续患者。通过A超超声生物测量法和超声生物显微镜测量双眼的生物测量参数。对视觉功能、基线眼压（IOP）和生物测量结果进行比较。
招募了41例患者。与患PAC/PACS的对侧眼相比，患CPACG的眼视觉功能更差、基线眼压更高、杯盘比更大（P<0.001）。与患PAC/PACS的对侧眼相比，患CPACG的眼前房深度更浅、前房角更小、虹膜更薄、虹膜睫状体距离更长（P<0.05）。晶状体厚度、眼轴长度、晶状体拱高和小梁睫状体距离方面无显著差异。
晶状体厚度、晶状体位置和眼轴长度在从PAC/PACS进展为CPACG的过程中似乎不起重要作用。虹膜薄且向前弯曲可能与从PAC/PACS进展为CPACG有关。
