感染与炎症性疾病
Infection and Inflammatory Diseases.
作者信息
Porritt Rebecca A, Crother Timothy R
机构信息
Division of Pediatric Infectious Diseases and Immunology, Burns and Allen Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
出版信息
For Immunopathol Dis Therap. 2016;7(3-4):237-254. doi: 10.1615/ForumImmunDisTher.2017020161.
, an obligate intracellular bacterial pathogen, has long been investigated as a potential developmental or exacerbating factor in various pathologies. Its unique lifestyle and ability to disseminate throughout the host while persisting in relative safety from the immune response has placed this obligate intracellular pathogen in the crosshairs as a potentially mitigating factor in chronic inflammatory diseases. Many animal model and human correlative studies have been performed to confirm or deny a role for infection in these disorders. In some cases, antibiotic clinical trials were conducted to prove a link between bacterial infections and atherosclerosis. In this review, we detail the latest information regarding the potential role that infection may have in chronic inflammatory diseases.
作为一种专性胞内细菌病原体，长期以来一直被研究为各种病理学中潜在的发育或加重因素。其独特的生活方式以及在宿主内传播同时相对安全地免受免疫反应影响的能力，使这种专性胞内病原体成为慢性炎症性疾病中潜在缓解因素的关注焦点。已经进行了许多动物模型和人类相关性研究，以证实或否定感染在这些疾病中的作用。在某些情况下，还进行了抗生素临床试验以证明细菌感染与动脉粥样硬化之间的联系。在本综述中，我们详细介绍了关于感染可能在慢性炎症性疾病中发挥的潜在作用的最新信息。
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