斑马鱼作为研究衰老、癌症及其他疾病中DNA损伤的新兴模型。
The Zebrafish as an Emerging Model to Study DNA Damage in Aging, Cancer and Other Diseases.
作者信息
Cayuela Maria Luisa, Claes Kathleen B M, Ferreira Miguel Godinho, Henriques Catarina Martins, van Eeden Fredericus, Varga Máté, Vierstraete Jeroen, Mione Maria Caterina
机构信息
Telomerase, Cancer and Aging Group, Surgery Unit, Instituto Murciano de Investigación Biosanitaria-Arrixaca, Murcia, Spain.
Center for Medical Genetics, Ghent University, Ghent, Belgium.
出版信息
Front Cell Dev Biol. 2019 Jan 10;6:178. doi: 10.3389/fcell.2018.00178. eCollection 2018.
Cancer is a disease of the elderly, and old age is its largest risk factor. With age, DNA damage accumulates continuously, increasing the chance of malignant transformation. The zebrafish has emerged as an important vertebrate model to study these processes. Key mechanisms such as DNA damage responses and cellular senescence can be studied in zebrafish throughout its life course. In addition, the zebrafish is becoming an important resource to study telomere biology in aging, regeneration and cancer. Here we review some of the tools and resources that zebrafish researchers have developed and discuss their potential use in the study of DNA damage, cancer and aging related diseases.
癌症是一种老年疾病，而老年是其最大的风险因素。随着年龄增长，DNA损伤不断累积，增加了恶性转化的几率。斑马鱼已成为研究这些过程的重要脊椎动物模型。诸如DNA损伤反应和细胞衰老等关键机制可以在斑马鱼的整个生命过程中进行研究。此外，斑马鱼正成为研究衰老、再生和癌症中端粒生物学的重要资源。在此，我们综述了斑马鱼研究人员开发的一些工具和资源，并讨论了它们在DNA损伤、癌症和衰老相关疾病研究中的潜在用途。
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