Rong Xingyan, Chen Han, Guo Xiyuan, Sun Xiaoke, Li Lin, Ye Yingchun, Li Chenwen, Nian Siji, Liang Chengbi, Yuan Qing
Public Center of Experimental Technology, The School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, China.
School of Stomatology, Southwest Medical University, Luzhou, Sichuan, China.
Front Immunol. 2025 Jul 10;16:1540610. doi: 10.3389/fimmu.2025.1540610. eCollection 2025.
Breast cancer (BC) tops the list of all malignancies diagnosed in women worldwide, with many patients diagnosed only at the metastatic stage. Current therapeutic paradigms integrating early detection modalities and multimodal treatment strategies have improved outcomes, yet persistent challenges in managing advanced/metastatic cases result in suboptimal 5-year survival rates. Therefore, it is imperative to develop novel therapeutic strategies for BC. Zebrafish breast cancer models have received great attention in this regard, and this review highlights recent advances in BC research involving these zebrafish models. research using zebrafish models is becoming increasingly valuable for studying BC invasion and metastasis, tumor angiogenesis, and screening for novel therapeutic molecules. These studies have provided insights into the molecular mechanisms of BC, potential drug targets and their efficacy and toxicity, and the application of zebrafish in personalized medicine research. Against this background, this review provides a systematic analysis of the recent advances in zebrafish BC model research regarding brain metastasis, bone metastasis, tumor angiogenesis, and drug screening. The review also critically evaluates the strengths and limitations of the zebrafish model organism, while delineating the future research directions in this field.
乳腺癌（BC）在全球女性确诊的所有恶性肿瘤中位居榜首，许多患者直到出现转移才被确诊。目前整合早期检测方法和多模式治疗策略的治疗模式改善了治疗结果，但在管理晚期/转移性病例方面仍存在持续挑战，导致5年生存率不尽人意。因此，开发针对乳腺癌的新型治疗策略势在必行。斑马鱼乳腺癌模型在这方面受到了极大关注，本综述重点介绍了涉及这些斑马鱼模型的乳腺癌研究的最新进展。利用斑马鱼模型进行的研究对于研究乳腺癌的侵袭和转移、肿瘤血管生成以及筛选新型治疗分子变得越来越有价值。这些研究为乳腺癌的分子机制、潜在药物靶点及其疗效和毒性，以及斑马鱼在个性化医学研究中的应用提供了见解。在此背景下，本综述对斑马鱼乳腺癌模型在脑转移、骨转移、肿瘤血管生成和药物筛选方面的研究进展进行了系统分析。该综述还批判性地评估了斑马鱼模式生物的优势和局限性，同时阐述了该领域未来的研究方向。
