Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.
State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai, China.
Biomed Res Int. 2018 Dec 30;2018:4902941. doi: 10.1155/2018/4902941. eCollection 2018.
Nontuberculous mycobacteria (NTM) cause various diseases in humans and animals. Recently, the prevalence of NTM-related disease has been on the rise, becoming an emerging public health problem. The aim of this study was to determine the antibiotic susceptibility profiles of clinical isolates of . We performed susceptibility tests on 37 clinical NTM isolates to 30 antibiotics with the microdilution method recommended by the Clinical and Laboratory Standards Institute.
Both and were highly resistant to antitubercular drugs such as isoniazid, rifampin, ethambutol, clofazimine, ethionamide, and rifabutin. showed the lowest resistant rates to cefoxitin (10%), azithromycin (10%), amikacin (10%), and clarithromycin (20%) and very high resistant to sulfamethoxazole, vancomycin, oxacillin, clindamycin, and all fluoroquinolones. showed low resistance to tigecycline (0%), tetracycline (0%), cefmetazole (12%), imipenem (12%), linezolid (18%), and the aminoglycosides amikacin (0%), tobramycin (0%), neomycin (0%), and gentamycin (24%).
Amikacin, cefoxitin, and azithromycin have the highest activity against . Isolates of need to be individually evaluated for drug susceptibility before choosing an effective antimicrobial regimen for treatment of infections.
非结核分枝杆菌（NTM）可引起人类和动物的各种疾病。最近，NTM 相关疾病的患病率一直在上升，成为一个新出现的公共卫生问题。本研究旨在确定临床分离株的抗生素敏感性谱。我们采用临床和实验室标准研究所推荐的微量稀释法对 37 株临床 NTM 分离株进行了 30 种抗生素的药敏试验。
和对异烟肼、利福平、乙胺丁醇、氯法齐明、乙硫异烟胺和利福布丁等抗结核药物均高度耐药。对头孢西丁（10%）、阿奇霉素（10%）、阿米卡星（10%）和克拉霉素（20%）的耐药率最低，对磺胺甲噁唑、万古霉素、苯唑西林、克林霉素和所有氟喹诺酮类药物的耐药率非常高。对替加环素（0%）、四环素（0%）、头孢美唑（12%）、亚胺培南（12%）、利奈唑胺（18%）和氨基糖苷类阿米卡星（0%）、妥布霉素（0%）、新霉素（0%）和庆大霉素（24%）的耐药率较低。
阿米卡星、头孢西丁和阿奇霉素对活性最高。在选择有效的抗菌治疗方案治疗感染之前，需要对的分离株进行药敏试验进行个体化评估。
