通过 1,5-氢原子转移（HAT）级联反应引发的亚胺基自由基引发的分子间远程 C(sp)-H 杂芳基化反应。
Iminyl Radical-Triggered Intermolecular Distal C(sp)-H Heteroarylation via 1,5-Hydrogen-Atom Transfer (HAT) Cascade.
机构信息
Department of Chemistry, School of Science, Xi'an Key Laboratory of Sustainable Energy Material Chemistry, and MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter , Xi'an Jiaotong University , Xi'an 710049 , China.
出版信息
Org Lett. 2019 Feb 15;21(4):917-920. doi: 10.1021/acs.orglett.8b03865. Epub 2019 Jan 28.
An efficient iron-catalyzed intermolecular remote C(sp)-H heteroarylation of alkyl ketones has been developed via an iminyl radical-triggered 1,5-hydrogen-atom transfer (HAT) cascade. This protocol was amenable to a wide variety of alkyl ketones and heteroaryls, thus providing a straightforward method for the late-stage functionalization of alkylketones and heteroaryls.
一种高效的铁催化的分子间远程 C(sp)-H 杂芳基化反应已通过亚胺基自由基引发的 1,5-氢原子转移（HAT）级联反应得到发展。该方法适用于多种烷基酮和杂芳基，因此为烷基酮和杂芳基的后期功能化提供了一种直接的方法。
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