在水中，喹喔啉-2(1)-酮与2,2-二氟-2-芳基乙酸钾发生光引发的脱羧C3-二氟芳基甲基化反应。
Photoinitiated decarboxylative C3-difluoroarylmethylation of quinoxalin-2(1)-ones with potassium 2,2-difluoro-2-arylacetates in water.
作者信息
Gao Yanhui, Zhao Lulu, Xiang Tianyi, Li Pinhua, Wang Lei
机构信息
Key Laboratory of Green and Precise Synthetic Chemistry and Applications, Ministry of Education, Department of Chemistry, Huaibei Normal University Huaibei Anhui 235000 P. R. China
College of Pharmacy, Shenyang Pharmaceutical University Shenyang 110016 P. R. China.
出版信息
RSC Adv. 2020 Mar 12;10(18):10559-10568. doi: 10.1039/d0ra02059a. eCollection 2020 Mar 11.
An efficient and green strategy for the preparation of C3-difluoroarylmethylated quinoxalin-2(1)-one a visible-light-induced decarboxylative C3-difluoroarylmethylation of quinoxalin-2(1)-one with potassium 2,2-difluoro-2-arylacetate in water at room temperature was developed. This photoinduced reaction generated the desired products in good yields under simple and mild conditions.
一种制备C3-二氟芳基甲基化喹喔啉-2(1)-酮的高效绿色策略——开发了一种在室温下于水中可见光诱导喹喔啉-2(1)-酮与2,2-二氟-2-芳基乙酸钾进行脱羧C3-二氟芳基甲基化反应的方法。该光诱导反应在简单温和的条件下以良好的产率生成了所需产物。
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